ArticleClinical and diagnostic laboratory immunology2005
Sensitivity and specificity of a monoclonal antibody-based fluorescence assay for detecting Enterocytozoon bieneusi spores in feces of simian immunodeficiency virus-infected macaques.
Article in Clinical and diagnostic laboratory immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 25 citations in OpenAlex.
- Mixed infection with multiple bacteria and microsporidia (Enterocytozoon bieneusi) in a post-renal transplant patient: a case report.BMC infectious diseases · 2026Article
- First molecular detection and multilocus genotyping of Enterocytozoon bieneusi from pigs in Guangxi Zhuang Autonomous region, Southern China.BMC veterinary research · 2025Article
- A new method of metabarcoding Microsporidia and their hosts reveals high levels of microsporidian infections in mosquitoes (Culicidae).Molecular ecology resources · 2020Article
- Evaluation of Immunoflourescence antibody assay for the detection of Enterocytozoon bieneusi and Encephalitozoon intestinalis.Parasitology research · 2016Article
- MyD88-dependent pathway is essential for the innate immunity to Enterocytozoon bieneusi.Parasite immunology · 2011Article
- Therapeutic evaluation of polyamine analogue drug candidates against Enterocytozoon bieneusi in a SCID mouse model.Antimicrobial agents and chemotherapy · 2009Article
- Molecular diagnostic tests for microsporidia.Interdisciplinary perspectives on infectious diseases · 2009Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Enterocytozoon bieneusi is clinically the most significant among the microsporidia causing chronic diarrhea, wasting, and cholangitis in individuals with human immunodeficiency virus/AIDS. Microscopy with either calcofluor or modified trichrome stains is the standard diagnostic test for microsporidiosis and does not allow species identification. Detection of E. bieneusi infection based on PCR is limited to a few reference laboratories, and thus it is not the standard diagnostic assay. We have recently reported the development and characterization of a panel of monoclonal antibodies against E. bieneusi, and in this publication we evaluated the specificity and sensitivity of an immunofluorescence assay (IFA), compared with PCR, in simian immunodeficiency virus-infected macaques. The IFA, which correlated with the primary PCR method, with a detection limit of 1.5 x 10(5) spores per gram of feces, will simplify considerably the detection of E. bieneusi spores in clinical and environmental specimens and in laboratory and epidemiological investigations.
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