ReviewThe Journal of physiology2006
Spontaneous activity of lower urinary tract smooth muscles: correlation between ion channels and tissue function.
Review in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 173 citations in OpenAlex.
- Ultrasound thickness of bladder wall in continent and incontinent women and its correlation with cystometry.TheScientificWorldJournal · 2014Trial
- Ion Channels as Therapeutic Targets in Overactive Bladder: A Narrative Review of Mechanisms, Translational Evidence, and Current Gaps.Lower urinary tract symptoms · 2026Review
- Cells and ionic conductances contributing to spontaneous activity in bladder and urethral smooth muscle.The Journal of physiology · 2026Review
- Pharmacological Separation of Mechanosensory Mechanisms in Rat Urinary Bladder Ex Vivo.Pharmacology research & perspectives · 2026Article
- Orai storeoperated CaChannels (Austin, Tex.) · 2025Review
- Ion-Channel Proteins in the Prepubertal Bitch Reproductive System: The Immunolocalization of ASIC2, ASIC4, and PIEZO2.International journal of molecular sciences · 2025Article
- The association between magnesium depletion score (MDS) and overactive bladder (OAB) among the U.S. population.Journal of health, population, and nutrition · 2025Article
- The functions of hydrogen sulfide on the urogenital system of both males and females: from inception to the present.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Biophysical Mechanisms of Vaginal Smooth Muscle Contraction: The Role of the Membrane Potential and Ion Channels.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024Review
- Causal effects of gut microbiota on risk of overactive bladder symptoms: a two-sample Mendelian randomization study.Frontiers in microbiology · 2024Article
- Advances in Assistive Electronic Device Solutions for Urology.Micromachines · 2022Review
- Tissue engineering in reconstructive urology-The current status and critical insights to set future directions-critical review.Frontiers in bioengineering and biotechnology · 2022Review
- Overactive bladder: A review and update.Experimental and therapeutic medicine · 2021Article
- Effect of Variations in Gap Junctional Coupling on the Frequency of Oscillatory Action Potentials in a Smooth Muscle Syncytium.Frontiers in physiology · 2021Article
- The intracellular CaProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Alterations in detrusor contractility in rat model of bladder cancer.Scientific reports · 2020Article
- Urinary bladder smooth muscle ion channels: expression, function, and regulation in health and disease.American journal of physiology. Renal physiology · 2020Review
- Preparation and Utilization of Freshly Isolated Human Detrusor Smooth Muscle Cells for Characterization of 9-Phenanthrol-Sensitive Cation Currents.Journal of visualized experiments : JoVE · 2020Article
- Asiatic Acid, a Natural Compound that Exerts Beneficial Effects on the Cystometric and Biochemical Parameters in the Retinyl Acetate-Induced Model of Detrusor Overactivity.Frontiers in pharmacology · 2020Article
- Urinary dysfunction in transgenic sickle cell mice: model of idiopathic overactive bladder syndrome.American journal of physiology. Renal physiology · 2019Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Smooth muscles from the urethra and bladder display characteristic patterns of spontaneous contractile activity in the filling phase of the micturition cycle. Tonic contractions are seen in the urethral smooth muscles, and phasic contractions occur in the detrusor. Overactivity in the detrusor is a common clinical problem. The ion channels in the smooth muscle membranes play an important role in determining the functional properties, and are obvious targets for treatment of the overactive bladder. Recent evidence suggests that interstitial cells may also play a role in determining the pattern of spontaneous activity, although their precise role is less well established in the urinary tract than in the gut. The ion channels involved in these cells are also of interest. This review discusses what is known of ion channels in these tissues, and their implications for function.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.