ArticleThe Journal of physiology2005
Kv1 channels selectively prevent dendritic hyperexcitability in rat Purkinje cells.
Article in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Characterizing molecular and behavioral changes arising from ROMK potassium channel deficiency in the cerebellum.Frontiers in behavioral neuroscience · 2025Article
- Human Purkinje cells outperform mouse Purkinje cells in dendritic complexity and computational capacity.Communications biology · 2024Article
- Mechanism of stress-induced attacks in an episodic neurologic disorder.Science advances · 2022Article
- Transmitter and ion channel profiles of neurons in the primate abducens and trochlear nuclei.Brain structure & function · 2021Article
- ATR regulates neuronal activity by modulating presynaptic firing.Nature communications · 2021Article
- GIRK1-Mediated Inwardly Rectifying Potassium Current Is a Candidate Mechanism Behind Purkinje Cell Excitability, Plasticity, and Neuromodulation.Cerebellum (London, England) · 2020Article
- The Emerging Concept of Intrinsic Plasticity: Activity-dependent Modulation of Intrinsic Excitability in Cerebellar Purkinje Cells and Motor Learning.Experimental neurobiology · 2018Review
- Purkinje Cell Signaling Deficits in Animal Models of Ataxia.Frontiers in synaptic neuroscience · 2018Review
- Intracerebellar infusion of the protein kinase M zeta (PKMζ) inhibitor zeta-inhibitory peptide (ZIP) disrupts eyeblink classical conditioning.Behavioral neuroscience · 2016Article
- Corticotropin-releasing factor increases Purkinje neuron excitability by modulating sodium, potassium, and Ih currents.Journal of neurophysiology · 2015Article
- Action potential processing in a detailed Purkinje cell model reveals a critical role for axonal compartmentalization.Frontiers in cellular neuroscience · 2015Article
- New insights into the pathogenesis and therapeutics of episodic ataxia type 1.Frontiers in cellular neuroscience · 2015Review
- Cerebellar secretin modulates eyeblink classical conditioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
- Article
- Consensus paper: pathological mechanisms underlying neurodegeneration in spinocerebellar ataxias.Cerebellum (London, England) · 2014Article
- A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets.The Journal of physiology · 2013Article
- Molecular mechanism for depolarization-induced modulation of Kv channel closure.The Journal of general physiology · 2012Article
- Contributions of T-type voltage-gated calcium channels to postsynaptic calcium signaling within Purkinje neurons.Cerebellum (London, England) · 2012Review
- Cellular mechanisms and behavioral consequences of Kv1.2 regulation in the rat cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Purkinje cells, the sole output of the cerebellar cortex, encode the timing signals required for motor coordination in their firing rate and activity pattern. Dendrites of Purkinje cells express a high density of P/Q-type voltage-gated calcium channels and fire dendritic calcium spikes. Here we show that dendritic subthreshold Kv1.2 subunit-containing Kv1 potassium channels prevent generation of random spontaneous calcium spikes. With Kv1 channels blocked, dendritic calcium spikes drive bursts of somatic sodium spikes and prevent the cell from faithfully encoding motor timing signals. The selective dendritic function of Kv1 channels in Purkinje cells allows them to effectively suppress dendritic hyperexcitability without hindering the generation of somatic action potentials. Further, we show that Kv1 channels also contribute to dendritic integration of parallel fibre synaptic input. Kv1 channels are often targeted to soma and axon and the data presented support a major dendritic function for these channels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.