Trial reportBMJ (Clinical research ed.)2005
Risk score for predicting death, myocardial infarction, and stroke in patients with stable angina, based on a large randomised trial cohort of patients.
Trial report in BMJ (Clinical research ed.), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01609465 (Prognostic Models for People With Stable Coronary Artery Disease), which is not on this map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prognostic Models for People With Stable Coronary Artery Disease
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Blood pressure-lowering treatment strategies based on cardiovascular risk versus blood pressure: A meta-analysis of individual participant data.PLoS medicine · 2018Pooled it
- Evaluating the quality of research into a single prognostic biomarker: a systematic review and meta-analysis of 83 studies of C-reactive protein in stable coronary artery disease.PLoS medicine · 2010Pooled it
- Individualized Angiotensin-Converting Enzyme (ACE)-Inhibitor Therapy in Stable Coronary Artery Disease Based on Clinical and Pharmacogenetic Determinants: The PERindopril GENEtic (PERGENE) Risk Model.Journal of the American Heart Association · 2016Trial
- The Helicobacter Eradication Aspirin Trial (HEAT): A Large Simple Randomised Controlled Trial Using Novel Methodology in Primary Care.EBioMedicine · 2015Trial
- Simple integer risk score to determine prognosis of patients with hypertension and chronic stable coronary artery disease.Journal of the American Heart Association · 2013Trial
- Mortality implications of angina and blood pressure in hypertensive patients with coronary artery disease: New data from extended follow-up of the International Verapamil/Trandolapril Study (INVEST).Clinical cardiology · 2013Trial
- Predictors of outcome and the lack of effect of percutaneous coronary intervention across the risk strata in patients with persistent total occlusion after myocardial infarction: Results from the OAT (Occluded Artery Trial) study.JACC. Cardiovascular interventions · 2008Trial
- Application Value of QRS Wave Potential in Predicting Left Ventricular Remodeling and Adverse Cardiovascular Events in Patients with Acute Myocardial Infarction After PCI.International journal of general medicine · 2026Article
- Natural history and outcomes of medically treated coronary artery disease: insights from reconstructed individual patient data of 29 randomized trials.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Estimating the Risk of Cardiovascular Events in U.S. Veterans Using the SMART Risk Score.JACC. Advances · 2025Article
- Effect of thyroid stimulating hormone on the prognosis of coronary heart disease.Frontiers in endocrinology · 2025Article
- Inflammation and platelet hyperresponsiveness in coronary artery disease and the influence of Talin-1/αIIbβ3-mediated bidirectional signaling pathway.Frontiers in pharmacology · 2025Article
- The Prognostic Significance of QTc Prolongation in Lead aVR in Patients with Acute Coronary Syndrome with ST Elevation or Depression.Medicina (Kaunas, Lithuania) · 2024Article
- Residual risks and evolving atherosclerotic plaques.Molecular and cellular biochemistry · 2023Review
- Age-Bilirubin-International Normalized Ratio (INR)-Creatinine (ABIC) Score, a Potential Prognostic Model for Long-Term Mortality of CAD Patients After PCI.Journal of inflammation research · 2023Article
- Post-systolic shortening is superior to global longitudinal strain in predicting adverse events in patients with stable coronary artery disease and preserved systolic function.Insights into imaging · 2022Article
- QT interval dynamics in patients with ST-elevation MI.Frontiers in cardiovascular medicine · 2022Article
- Machine learning approaches improve risk stratification for secondary cardiovascular disease prevention in multiethnic patients.Open heart · 2021Article
- Simple risk models to predict cardiovascular death in patients with stable coronary artery disease.European heart journal. Quality of care & clinical outcomes · 2021Article
- The myth of 'stable' coronary artery disease.Nature reviews. Cardiology · 2020Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo derive a risk score for the combination of death from all causes, myocardial infarction, and disabling stroke in patients with stable symptomatic angina who require treatment for angina and have preserved left ventricular function.
designMultivariate Cox regression analysis of data from a large multicentre trial.
settingOutpatient cardiology clinics in western Europe, Israel, Canada, Australia, and New Zealand.
participants7311 patients with all required data available.
main outcome measureDeath from any cause or myocardial infarction or disabling stroke during a mean follow-up of 4.9 years.
results1063 patients either died from any cause or sustained myocardial infarction or disabling stroke. The five year risk of this composite ranged from 4% for patients in the lowest tenth of risk to 35% for patients in the highest tenth. The risk score combines 16 routinely available clinical variables (in order of decreasing contribution): age, left ventricular ejection fraction, smoking, white blood cell count, diabetes, casual blood glucose concentration, creatinine concentration, previous stroke, at least one angina attack a week, coronary angiographic findings (if available), lipid lowering treatment, QT interval, systolic blood pressure > or = 155 mm Hg, number of drugs used for angina, previous myocardial infarction, and sex. Fitting the same model separately to all cause death, myocardial infarction, and stroke gave similar results. The risk score did not seem to predict the nature of the event (death in 39%, myocardial infarction in 46%, and disabling stroke in 15%) or the incidence of angiography or revascularisation, which occurred in 29% of patients.
conclusionThis risk score is an objective aid in deciding on further management of patients with stable angina with the aim of reducing serious outcome events. The score can also be used in planning future trials.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.