ArticleGenes and immunity2005
A non-conservative, coding single-nucleotide polymorphism in the N-terminal region of lactoferrin is associated with aggressive periodontitis in an African-American, but not a Caucasian population.
Article in Genes and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
- Analysis of new lactotransferrin gene variants in a case-control study related to periodontal disease in dog.Molecular biology reports · 2012Trial
- Association Between Lactoferrin Gene Polymorphism and Dental Caries in Saudi Children: A Case-Control Study.Cureus · 2025Article
- Salivary Lactoferrin Levels and Polymorphisms in Down Syndrome Individuals with Periodontitis.Journal of clinical medicine · 2025Article
- Association of RS1126478 (LTF) with molar-incisor and generalized periodontitis.Clinical oral investigations · 2024Article
- Grade C Molar-Incisor Pattern Periodontitis in Young Adults: What Have We Learned So Far?Pathogens (Basel, Switzerland) · 2024Review
- Exploring the Role of Lactoferrin in Managing Allergic Airway Diseases among Children: Unrevealing a Potential Breakthrough.Nutrients · 2024Review
- The Genetic Aspects of Periodontitis Pathogenesis and the Regenerative Properties of Stem Cells.Cells · 2024Review
- Etiology of aggressive periodontitis in individuals of African descent.The Japanese dental science review · 2021Review
- Periodontal health and disease: The contribution of genetics.Periodontology 2000 · 2021Review
- Genetic polymorphisms and periodontal disease in populations of African descent: A review.Journal of periodontal research · 2018Review
- Cardiometabolic risk factors and lactoferrin: polymorphisms and plasma levels in French-Canadian children.Pediatric research · 2017Article
- Microbial Community Composition Impacts Pathogen Iron Availability during Polymicrobial Infection.PLoS pathogens · 2016Article
- Lactoferrin: A Roadmap to the Borderland between Caries and Periodontal Disease.Journal of dental research · 2015Review
- Lactotransferrin gene functional polymorphisms do not influence susceptibility to human immunodeficiency virus-1 mother-to-child transmission in different ethnic groups.Memorias do Instituto Oswaldo Cruz · 2015Article
- Gene polymorphism of β-defensin-1 is associated with susceptibility to periodontitis in Japanese.Odontology · 2015Article
- Identification of common genetic variants that account for transcript isoform variation between human populations.Human genetics · 2009Article
- Salivary biomarkers for clinical applications.Molecular diagnosis & therapy · 2009Review
- Evaluation of genetic variation contributing to differences in gene expression between populations.American journal of human genetics · 2008Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Lactoferrin is an antimicrobial protein which plays an important role in regulating bacteria that are associated with aggressive periodontitis. Lactoferrin kills directly (via its strongly cationic N-terminal region) and indirectly, through sequestering the iron that bacteria require for growth. As aggressive periodontitis has a strong heritable component, we hypothesized that genetic variation within the lactoferrin gene may play a role in susceptibility to this condition. We have identified and examined a novel, functional, single-point A/G nucleotide mutation causing a threonine/alanine substitution at position 11 (T11A) of the secreted lactoferrin protein. In a pilot case-controlled study of aggressive periodontitis, analysis of 46 African-American patients and 78 controls showed that patients were twice as likely to express the G nucleotide (alanine) allele over controls (60.3 vs 30.4%; P=0.0007, odds ratio=2.564, 95% CI=1.475-4.459). A Caucasian population of 77 patients and 131 controls showed no such association (P=0.5201, odds ratio=0.862, 95% CI=0.548-1.356). The data presented provide a new insight into the genetic susceptibility to aggressive periodontitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.