ArticleJournal of clinical microbiology2005
Diversity of potential short tandem repeats in Mycobacterium leprae and application for molecular typing.
Article in Journal of clinical microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Pathogenicity and virulence ofVirulence · 2022Review
- Human Leukocyte Antigen Fine-Mapping and Correlation Analysis of Han and Minority Leprosy Patients in Southern China.Frontiers in genetics · 2022Article
- Genotyping comparison of Mycobacterium leprae isolates by VNTR analysis from nasal samples in a Brazilian endemic region.Pathogens and global health · 2018Article
- Genotyping of Mycobacterium leprae for better understanding of leprosy transmission in Fortaleza, Northeastern Brazil.PLoS neglected tropical diseases · 2017Article
- Whole genome sequencing distinguishes between relapse and reinfection in recurrent leprosy cases.PLoS neglected tropical diseases · 2017Article
- Molecular, ethno-spatial epidemiology of leprosy in China: novel insights for tracing leprosy in endemic and non endemic provinces.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2013Article
- Mycobacterium leprae in Colombia described by SNP7614 in gyrA, two minisatellites and geography.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2013Article
- Real-time PCR and high-resolution melt analysis for rapid detection of Mycobacterium leprae drug resistance mutations and strain types.Journal of clinical microbiology · 2012Article
- Molecular typing of Mycobacterium leprae strains from northern India using short tandem repeats.The Indian journal of medical research · 2011Article
- Transmission of leprosy in Qiubei County, Yunnan, China: insights from an 8-year molecular epidemiology investigation.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2011Article
- Mycobacterium leprae: genes, pseudogenes and genetic diversity.Future microbiology · 2011Review
- Evidence for an association of HLA-DRB1*15 and DRB1*09 with leprosy and the impact of DRB1*09 on disease onset in a Chinese Han population.BMC medical genetics · 2009Article
- Comparative genomic and phylogeographic analysis of Mycobacterium leprae.Nature genetics · 2009Article
- Population-based molecular epidemiology of leprosy in Cebu, Philippines.Journal of clinical microbiology · 2009Article
- Rapid variable-number tandem-repeat genotyping for Mycobacterium leprae clinical specimens.Journal of clinical microbiology · 2009Article
- Variable number tandem repeat loci providing discrimination within widespread genotypes of Acinetobacter baumannii.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2009Article
- Combined multilocus short-sequence-repeat and mycobacterial interspersed repetitive unit-variable-number tandem-repeat typing of Mycobacterium avium subsp. paratuberculosis isolates.Journal of clinical microbiology · 2008Article
- Are variable-number tandem repeats appropriate for genotyping Mycobacterium leprae?Journal of clinical microbiology · 2008Article
- Use of short tandem repeat sequences to study Mycobacterium leprae in leprosy patients in Malawi and India.PLoS neglected tropical diseases · 2008Article
- An analysis of the epitope knowledge related to Mycobacteria.Immunome research · 2007Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A recent advance in molecular typing for tracing the transmission of leprosy is the discovery of short tandem repeats (STRs) in Mycobacterium leprae. To substantiate polymorphic loci from STR as promising candidates for molecular typing tools in leprosy epidemiology, 44 STR loci including 33 microsatellites and 11 minisatellites were investigated among 27 laboratory strains by sequencing PCR products. Not all STRs were necessarily polymorphic. Thirty-two out of the 44 loci were polymorphic. Nine polymorphic loci were suitable for identifying genotypes according to the discriminatory capacity, stability, and reproducibility. All the strains were classified into independent genotypes by the selected nine loci. Three multi-case households were subjected to molecular typing. M. leprae obtained from household cases showed identical copy numbers by TTC triplet alone, but the isolates from one family contact case were divided into different genotypes by adding eight other polymorphic loci. The combination of information from multiple loci allows increasing levels of discrimination and it is likely that the generation and documentation of data will result in the choice of a potential molecular typing tool for leprosy epidemiology.
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