ArticleJournal of clinical microbiology2005
Transmission of Burkholderia cepacia complex: evidence for new epidemic clones infecting cystic fibrosis patients in Italy.
Article in Journal of clinical microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 50 citations in OpenAlex.
- Colony morphotype variation inJournal of bacteriology · 2025Review
- Burkholderia contaminans Bacteriophage CSP3 Requires O-Antigen Polysaccharides for Infection.Microbiology spectrum · 2023Article
- High Genomic Identity between Clinical and Environmental Strains ofAntibiotics (Basel, Switzerland) · 2021Article
- Distribution of Burkholderia cepacia complex species isolated from industrial processes and contaminated products in Argentina.International microbiology : the official journal of the Spanish Society for Microbiology · 2021Article
- Impact of clonally-related Burkholderia contaminans strains in two patients attending an Italian cystic fibrosis centre: a case report.BMC pulmonary medicine · 2019Article
- RefractoryBMJ case reports · 2019Article
- Indole-3-Acetic Acid inFrontiers in microbiology · 2019Article
- Gut microbiota signatures in cystic fibrosis: Loss of host CFTR function drives the microbiota enterophenotype.PloS one · 2018Article
- Burkholderia cepacia complex in cystic fibrosis in a Brazilian reference center.Medical microbiology and immunology · 2017Article
- Complete Genome Sequence ofGenome announcements · 2017Article
- Review
- SNaPBceBcon: a Practical Tool for Identification and Genotyping of Burkholderia cepacia and Burkholderia contaminans.Journal of clinical microbiology · 2016Article
- Development of a multiple-locus variable-number tandem-repeat typing scheme for genetic fingerprinting of Burkholderia cenocepacia and application to nationwide epidemiological analysis.Journal of clinical microbiology · 2015Article
- Genetic diversity of Burkholderia contaminans isolates from cystic fibrosis patients in Argentina.Journal of clinical microbiology · 2013Article
- Structure of Burkholderia cepacia UDP-glucose dehydrogenase (UGD) BceC and role of Tyr10 in final hydrolysis of UGD thioester intermediate.Journal of bacteriology · 2011Article
- Unusual distribution of Burkholderia cepacia complex species in Danish cystic fibrosis clinics may stem from restricted transmission between patients.Journal of clinical microbiology · 2010Article
- The changing microbial epidemiology in cystic fibrosis.Clinical microbiology reviews · 2010Review
- Variation of the antimicrobial susceptibility profiles of Burkholderia cepacia complex clonal isolates obtained from chronically infected cystic fibrosis patients: a five-year survey in the major Portuguese treatment center.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2008Article
- Diversity of cultivated endophytic bacteria from sugarcane: genetic and biochemical characterization of Burkholderia cepacia complex isolates.Applied and environmental microbiology · 2007Article
- Clinical and environmental Burkholderia strains: biofilm production and intracellular survival.Current microbiology · 2007Article
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Authors and funding
24 authors at 13 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To analyze national prevalence, genomovar distribution, and epidemiology of the Burkholderia cepacia complex in Italy, 225 putative B. cepacia complex isolates were obtained from 225 cystic fibrosis (CF) patients attending 18 CF centers. The genomovar status of these isolates was determined by a polyphasic approach, which included whole-cell protein electrophoresis and recA restriction fragment length polymorphism (RFLP) analysis. Two approaches were used to genotype B. cepacia complex isolates: BOX-PCR fingerprinting and pulsed-field gel electrophoresis (PFGE) of genomic macrorestriction fragments. A total of 208 (92%) of 225 isolates belonged to the B. cepacia complex, with Burkholderia cenocepacia as the most prevalent species (61.1%). Clones delineated by PFGE were predominantly linked to a single center; in contrast, BOX-PCR clones were composed of isolates collected either from the same center or from different CF centers and comprised multiple PFGE clusters. Three BOX-PCR clones appeared of special interest. One clone was composed of 17 B. cenocepacia isolates belonging to recA RFLP type H. These isolates were collected from six centers and represented three PFGE clusters. The presence of insertion sequence IS 1363 in all isolates and the comparison with PHDC reference isolates identified this clone as PHDC, an epidemic clone prominent in North American CF patients. The second clone included 22 isolates from eight centers and belonged to recA RFLP type AT. The genomovar status of strains with the latter RFLP type is not known. Most of these isolates belonged to four different PFGE clusters. Finally, a third clone comprised nine B. pyrrocinia isolates belonging to recA RFLP type Se 13. They represented three PFGE clusters and were collected in three CF centers.
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