ArticleJournal of clinical microbiology2005
Diagnosis of cerebral toxoplasmosis in AIDS patients in Brazil: importance of molecular and immunological methods using peripheral blood samples.
Article in Journal of clinical microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 131 citations in OpenAlex.
- Genotyping of human isolates from human toxoplasmosis outbreak: Restriction Fragment Length Polymorphism and Sanger Sequencing.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Seroepidemiological study on coinfection of toxoplasmosis and active tuberculosis in Northern Iran: a case control study.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2024Article
- Seronegative Infection withJournal of clinical medicine · 2022Article
- Approach to an Intracranial Mass in Patients With HIV.Current neurology and neuroscience reports · 2020Review
- Genetic characterization ofParasitology · 2020Article
- Evaluation of a PCR assay for diagnosis of toxoplasmosis in serum and peripheral blood mononuclear cell among HIV/AIDS patients.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2020Article
- Image Diagnosis: Eccentric Target Sign of Focal Toxoplasma Encephalitis.The Permanente journal · 2020Article
- Pulmonary Toxoplasmosis Diagnosed on Transbronchial Lung Biopsy in a Mechanically Ventilated Patient.Case reports in infectious diseases · 2020Article
- Prevalence ofIranian journal of pathology · 2019Article
- Evaluation of Serological and Molecular Tests Used for the Identification ofFrontiers in cellular and infection microbiology · 2019Article
- Toxoplasma infection in individuals in central Italy: does a gender-linked risk exist?European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Article
- Evaluating the presence of Toxoplasma gondii in peripheral blood of patients with diverse forms of uveitis.International ophthalmology · 2017Article
- HIV-associated opportunistic CNS infections: pathophysiology, diagnosis and treatment.Nature reviews. Neurology · 2016Review
- Cerebro-meningeal infections in HIV-infected patients: a study of 116 cases in Libreville, Gabon.African health sciences · 2016Article
- Performance Testing of PCR Assay in Blood Samples for the Diagnosis of Toxoplasmic Encephalitis in AIDS Patients from the French Departments of America and Genetic Diversity of Toxoplasma gondii: A Prospective and Multicentric Study.PLoS neglected tropical diseases · 2016Article
- PCR-based detection of Toxoplasma gondii DNA in blood and ocular samples for diagnosis of ocular toxoplasmosis.Journal of clinical microbiology · 2014Article
- Genotype analysis of T. gondii strains associated with human infection in Egypt.Parasitology research · 2014Article
- Cerebral and ocular toxoplasmosis related with IFN-γ, TNF-α, and IL-10 levels.Frontiers in microbiology · 2014Article
- Toxoplasmosis.Handbook of clinical neurology · 2013Article
- Brain Tissue Cysts in Infected Mice with RH-Strain of Toxoplasma gondii and Evaluation of BAG1 and SAG1 Genes Expression.Iranian journal of parasitology · 2013Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebral toxoplasmosis is the most common cerebral focal lesion in AIDS and still accounts for high morbidity and mortality in Brazil. Its occurrence is more frequent in patients with low CD4(+) T-cell counts. It is directly related to the prevalence of anti-Toxoplasma gondii antibodies in the population. Therefore, it is important to evaluate sensitive, less invasive, and rapid diagnostic tests. We evaluated the value of PCR using peripheral blood samples on the diagnosis of cerebral toxoplasmosis and whether its association with immunological assays can contribute to a timely diagnosis. We prospectively analyzed blood samples from 192 AIDS patients divided into two groups. The first group was composed of samples from 64 patients with cerebral toxoplasmosis diagnosed by clinical and radiological features. The second group was composed of samples from 128 patients with other opportunistic diseases. Blood collection from patients with cerebral toxoplasmosis was done before or on the third day of anti-toxoplasma therapy. PCR for T. gondii, indirect immunofluorescence, enzyme-linked immunosorbent assay, and an avidity test for toxoplasmosis were performed on all samples. The PCR sensitivity and specificity for diagnosis of cerebral toxoplasmosis in blood were 80% and 98%, respectively. Patients with cerebral toxoplasmosis (89%) presented higher titers of anti-T. gondii IgG antibodies than patients with other diseases (57%) (P<0.001). These findings suggest the clinical value of the use of both PCR and high titers of anti-T. gondii IgG antibodies for the diagnosis of cerebral toxoplasmosis. This strategy may prevent more invasive approaches.
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