ArticleMicrobiology (Reading, England)2005
Allyl alcohol and garlic (Allium sativum) extract produce oxidative stress in Candida albicans.
Article in Microbiology (Reading, England), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 109 citations in OpenAlex.
- New antifungal strategies and drug development against WHO critical priority fungal pathogens.Frontiers in cellular and infection microbiology · 2025Review
- Advancements in Herbal Drug Loaded Nanoparticulate System for Antimicrobial Effect.Current topics in medicinal chemistry · 2025Review
- Use of red, far-red, and near-infrared light in imaging of yeasts and filamentous fungi.Applied microbiology and biotechnology · 2022Review
- Metabolic, structural, and proteomic changes in Candida albicans cells induced by the protein-carbohydrate fraction of Dendrobaena veneta coelomic fluid.Scientific reports · 2021Article
- Piperidine based 1,2,3-triazolylacetamide derivatives induce cell cycle arrest and apoptotic cell death inJournal of advanced research · 2021Article
- Facile Bio-Fabrication of Ag-Cu-Co Trimetallic Nanoparticles and Its Fungicidal Activity againstJournal of fungi (Basel, Switzerland) · 2021Article
- Diallyl Disulfide (DADS) Ameliorates IntestinalFrontiers in cellular and infection microbiology · 2021Article
- Article
- Temporal metabolic partitioning of the yeast and protist cellular networks: the cell is a global scale-invariant (fractal or self-similar) multioscillator.Journal of biomedical optics · 2018Article
- Ethnoveterinary perspectives and promising future.International journal of veterinary science and medicine · 2018Review
- Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress.Nutrients · 2018Article
- Antifungal Compounds againstBioMed research international · 2017Review
- The Antimicrobial Peptides P-113Du and P-113Tri Function against Candida albicans.Antimicrobial agents and chemotherapy · 2016Article
- Allicin Induces Calcium and Mitochondrial Dysregulation Causing Necrotic Death in Leishmania.PLoS neglected tropical diseases · 2016Article
- In Vitro Antibacterial Mechanism of Action of Crude Garlic (Allium sativum) Clove Extract on Selected Probiotic Bifidobacterium Species as Revealed by SEM, TEM, and SDS-PAGE Analysis.Probiotics and antimicrobial proteins · 2014Article
- An actinomycete isolate from solitary wasp mud nest having strong antibacterial activity and kills the Candida cells due to the shrinkage and the cytosolic loss.Frontiers in microbiology · 2014Article
- What yeast and cardiomyocytes share: ultradian oscillatory redox mechanisms of cellular coherence and survival.Integrative biology : quantitative biosciences from nano to macro · 2012Review
- Effect of marine polyunsaturated fatty acids on biofilm formation of Candida albicans and Candida dubliniensis.Marine drugs · 2010Article
- Diallyl disulphide depletes glutathione in Candida albicans: oxidative stress-mediated cell death studied by two-photon microscopy.Yeast (Chichester, England) · 2007Article
- Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status.The Journal of biological chemistry · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Both the growth and respiration of Candida albicans are sensitive to extracts of Allium sativum and investigations into the anticandidal activities are now focussing on the purified constituents to determine the targets of inhibition. Of particular interest is allyl alcohol (AA), a metabolic product that accumulates after trituration of garlic cloves. Putative targets for AA were investigated by monitoring changes in intracellular responses after exposure of C. albicans cells to AA or a commercially available garlic extract. Two-photon laser scanning microscopy and other techniques were used. Changes typical of oxidative stress--NADH oxidation and glutathione depletion, and increased reactive oxygen species--were observed microscopically and by flow cytometry. Known targets for AA are alcohol dehydrogenases Adh1 and 2 (in the cytosol) and Adh3 (mitochondrial), although the significant decrease in NAD(P)H after addition of AA is indicative of another mechanism of action.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.