ReviewSchizophrenia bulletin2006
Risk and protection in prodromal schizophrenia: ethical implications for clinical practice and future research.
Review in Schizophrenia bulletin, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 232 citations in OpenAlex.
- Impacts of risk thresholds and age on clinical high risk for psychosis: a comparative network analysis.European archives of psychiatry and clinical neuroscience · 2025Article
- Reciprocal Social Behavior and Related Social Outcomes in Individuals at Clinical High Risk for Psychosis.Psychiatry research · 2021Article
- Emerging therapeutic targets for schizophrenia: a framework for novel treatment strategies for psychosis.Expert opinion on therapeutic targets · 2021Review
- A review of negative symptom assessment strategies in youth at clinical high-risk for psychosis.Schizophrenia research · 2020Review
- Coping with family stress in individuals at clinical high-risk for psychosis.Schizophrenia research · 2020Article
- Adolescents at clinical high risk for psychosis show qualitatively altered patterns of activation during rule learning.NeuroImage. Clinical · 2020Article
- A predictive model for conversion to psychosis in clinical high-risk patients.Psychological medicine · 2019Article
- Compensatory Cognitive Training for Latino Youth at Clinical High Risk for Psychosis: Study Protocol for a Randomized Controlled Trial.Frontiers in psychiatry · 2019Article
- NEURAPRO: a multi-centre RCT of omega-3 polyunsaturated fatty acids versus placebo in young people at ultra-high risk of psychotic disorders-medium-term follow-up and clinical course.NPJ schizophrenia · 2018Article
- Lack of Diagnostic Pluripotentiality in Patients at Clinical High Risk for Psychosis: Specificity of Comorbidity Persistence and Search for Pluripotential Subgroups.Schizophrenia bulletin · 2018Article
- Course of clinical high-risk states for psychosis beyond conversion.European archives of psychiatry and clinical neuroscience · 2018Article
- Two-Year Clinical and Functional Outcomes of an Asian Cohort at Ultra-High Risk of Psychosis.Frontiers in psychiatry · 2018Article
- Can Peripheral Blood-Derived Gene Expressions Characterize Individuals at Ultra-high Risk for Psychosis?Computational psychiatry (Cambridge, Mass.) · 2017Article
- Anxiety in youth at clinical high risk for psychosis.Early intervention in psychiatry · 2017Article
- Baseline demographics, clinical features and predictors of conversion among 200 individuals in a longitudinal prospective psychosis-risk cohort.Psychological medicine · 2017Article
- A Severity-Based Clinical Staging Model for the Psychosis Prodrome: Longitudinal Findings From the New York Recognition and Prevention Program.Schizophrenia bulletin · 2017Article
- Disruptions in neural connectivity associated with reduced susceptibility to a depth inversion illusion in youth at ultra high risk for psychosis.NeuroImage. Clinical · 2016Article
- Emotion recognition deficits as predictors of transition in individuals at clinical high risk for schizophrenia: a neurodevelopmental perspective.Psychological medicine · 2015Article
- Reasons for cannabis use among youths at ultra high risk for psychosis.Early intervention in psychiatry · 2015Article
- Interaction of social role functioning and coping in people with recent-onset attenuated psychotic symptoms: a case study of three Chinese women at clinical high risk for psychosis.Neuropsychiatric disease and treatment · 2015Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Over the last decade schizophrenia researchers have turned their attention to earlier identification in the prodromal period of illness. A greater understanding of both risk and protective factors can lead to improved prevention and treatment strategies in this vulnerable population. This research, however, has far-reaching ethical implications. One year follow-up data from 50 individuals who met established criteria for a prodromal state is used to illustrate ethical issues that directly affect clinicians and future research strategies. At 1-year follow-up, the psychotic transition rate was 13%, but it increased in subsequent years with smaller sample sizes. One-half developed an affective psychosis. The converted sample was older (p > 0.05) than the nonconverted sample and more likely to have a premorbid history of substance abuse, as well as higher clinical ratings on "subsyndromal" psychotic items (delusional thinking, suspiciousness, and thought disorder). Despite a lack of conversion, the nonconverted sample remained symptomatic and had a high rate of affective and anxiety disorders with evidence of functional disability. This conversion rate is relatively low compared to similar studies at 1 year. Specific risk factors were identified, but these findings need to be replicated in a larger cohort. By examining the rate of conversion and nonconversion in this sample as an example, we hope to contribute to the discussion of implications for clinical practice and the direction of future research in the schizophrenia prodrome. Finally, our data strengthen the evidence base available to inform the discussion of ethical issues relevant to this important research area.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.