ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Juxtacellular recording/labeling analysis of physiological and anatomical characteristics of rat intergeniculate leaflet neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 44 citations in OpenAlex.
- Anatomy of hypothalamic and diencephalic nuclei involved in seasonal fertility regulation in ewes.Frontiers in veterinary science · 2023Article
- Visual Information Processing in the Ventral Division of the Mouse Lateral Geniculate Nucleus of the Thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Commissural communication allows mouse intergeniculate leaflet and ventral lateral geniculate neurons to encode interocular differences in irradiance.The Journal of physiology · 2018Article
- Geniculohypothalamic GABAergic projections gate suprachiasmatic nucleus responses to retinal input.The Journal of physiology · 2017Article
- Not a one-trick pony: Diverse connectivity and functions of the rodent lateral geniculate complex.Visual neuroscience · 2017Review
- Using light to tell the time of day: sensory coding in the mammalian circadian visual network.The Journal of experimental biology · 2016Review
- Age-related changes in neurochemical components and retinal projections of rat intergeniculate leaflet.Age (Dordrecht, Netherlands) · 2016Article
- Spontaneous activity does not predict morphological type in cerebellar interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Relaxin-3/RXFP3 networks: an emerging target for the treatment of depression and other neuropsychiatric diseases?Frontiers in pharmacology · 2014Review
- Neuroanatomy of the extended circadian rhythm system.Experimental neurology · 2013Review
- PIP2-mediated HCN3 channel gating is crucial for rhythmic burst firing in thalamic intergeniculate leaflet neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Reelin is required for class-specific retinogeniculate targeting.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The thalamic intergeniculate leaflet (IGL) is involved in mediating effects of both photic and nonphotic stimuli on mammalian circadian rhythms. IGL neurons containing neuropeptide Y (NPY) have been implicated in mediating nonphotic effects, but little is known about those involved in photic entrainment. We used juxtacellular recording/labeling in rats to characterize both photic responses and neurochemical phenotypes of neurons in the lateral geniculate area, focusing on the IGL and ventral lateral geniculate (VLG). Single neurons were recorded to characterize photic responsiveness and were labeled with Neurobiotin (Nb); tissue was stained for Nb, NPY, and in some cases for orexin A. Three classes of neurons were identified in the IGL/VLG. Type I neurons lacked NPY and showed sustained activations during retinal illumination and moderate firing rates in darkness. Type II neurons contained large amounts of NPY throughout the soma and showed varied responses to illumination: suppression, complex responses, or no response. Type III neurons had patches of NPY both on the external soma surface and within the soma, apparently representing internalization of NPY. Type III neurons resembled type I cells in their sustained activation by illumination but were virtually silent during the intervening dark period. These neurons appear to receive NPY input, presumably from other IGL cells, which may suppress their activity during darkness. These results demonstrate the presence of several classes of neurons in the IGL defined by their functional and anatomical features and reinforce the role of the IGL/VLG complex in integrating photic and nonphotic inputs to the circadian system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.