ArticleCardiovascular diabetology2005
Distinct effects of glucose and glucosamine on vascular endothelial and smooth muscle cells: evidence for a protective role for glucosamine in atherosclerosis.
Article in Cardiovascular diabetology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 57 citations in OpenAlex.
- Sulfoconjugation of protein peptides and glycoproteins in physiology and diseases.Pharmacology & therapeutics · 2023Review
- Antioxidant activity of glucosamine and its effects on ROS production, Nrf2, and O-GlcNAc expression in HMEC-1 cells.Current research in toxicology · 2023Article
- The role of type 2 diabetes in the association between habitual glucosamine use and dementia: a prospective cohort study.Alzheimer's research & therapy · 2022Article
- Review
- Neuroprotective and Proneurogenic Effects of Glucosamine in an Internal Carotid Artery Occlusion Model of Ischemia.Neuromolecular medicine · 2022Article
- Risk of ischaemic stroke among new users of glucosamine and chondroitin sulphate: a nested case-control study.Therapeutic advances in musculoskeletal disease · 2022Article
- Review of Alterations in Perlecan-Associated Vascular Risk Factors in Dementia.International journal of molecular sciences · 2020Review
- Association of habitual glucosamine use with risk of cardiovascular disease: prospective study in UK Biobank.BMJ (Clinical research ed.) · 2019Article
- Identification of Metabolites Associated with Onset of CAD in Diabetic Patients Using CE-MS Analysis: A Pilot Study.Journal of atherosclerosis and thrombosis · 2019Article
- Chitosan based metallic nanocomposite scaffolds as antimicrobial wound dressings.Bioactive materials · 2018Review
- ProteinFrontiers in endocrinology · 2018Review
- Shear-induced endothelial NOS activation and remodeling via heparan sulfate, glypican-1, and syndecan-1.Integrative biology : quantitative biosciences from nano to macro · 2014Article
- Hyperglycemia induces altered expressions of angiogenesis associated molecules in the trophoblast.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Use of glucosamine and chondroitin in relation to mortality.European journal of epidemiology · 2012Article
- The structural stability of the endothelial glycocalyx after enzymatic removal of glycosaminoglycans.PloS one · 2012Article
- Article
- Endothelial argininosuccinate synthetase 1 regulates nitric oxide production and monocyte adhesion under static and laminar shear stress conditions.The Journal of biological chemistry · 2011Article
- Glycogen synthase kinase 3 beta mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1.The Journal of endocrinology · 2010Article
- Total mortality risk in relation to use of less-common dietary supplements.The American journal of clinical nutrition · 2010Article
- Interplay of anionic charge, poly(ethylene glycol), and iodinated tyrosine incorporation within tyrosine-derived polycarbonates: Effects on vascular smooth muscle cell adhesion, proliferation, and motility.Journal of biomedical materials research. Part A · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accelerated atherosclerosis is one of the major vascular complications of diabetes. Factors including hyperglycemia and hyperinsulinemia may contribute to accelerated vascular disease. Among the several mechanisms proposed to explain the link between hyperglycemia and vascular dysfunction is the hexosamine pathway, where glucose is converted to glucosamine. Although some animal experiments suggest that glucosamine may mediate insulin resistance, it is not clear whether glucosamine is the mediator of vascular complications associated with hyperglycemia. Several processes may contribute to diabetic atherosclerosis including decreased vascular heparin sulfate proteoglycans (HSPG), increased endothelial permeability and increased smooth muscle cell (SMC) proliferation. In this study, we determined the effects of glucose and glucosamine on endothelial cells and SMCs in vitro and on atherosclerosis in apoE null mice. Incubation of endothelial cells with glucosamine, but not glucose, significantly increased matrix HSPG (perlecan) containing heparin-like sequences. Increased HSPG in endothelial cells was associated with decreased protein transport across endothelial cell monolayers and decreased monocyte binding to subendothelial matrix. Glucose increased SMC proliferation, whereas glucosamine significantly inhibited SMC growth. The antiproliferative effect of glucosamine was mediated via induction of perlecan HSPG. We tested if glucosamine affects atherosclerosis development in apoE-null mice. Glucosamine significantly reduced the atherosclerotic lesion in aortic root. (P < 0.05) These data suggest that macrovascular disease associated with hyperglycemia is unlikely due to glucosamine. In fact, glucosamine by increasing HSPG showed atheroprotective effects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.