ArticleCell communication and signaling : CCS2005
Effect of connective tissue growth factor (CCN2/CTGF) on proliferation and differentiation of mouse periodontal ligament-derived cells.
Article in Cell communication and signaling : CCS, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 54 citations in OpenAlex.
- Inflammation-driven periostin in ECRS has contrasting effects on tissue structural integrity and osteitis.Frontiers in immunology · 2025Article
- Gradient boosting-based classification of interactome hub genes in periimplantitis with periodontitis - an integrated bioinformatic approach.Frontiers in oral health · 2024Article
- Do not overwork: cellular communication network factor 3 for life in cartilage.Journal of cell communication and signaling · 2023Review
- Molecular and Genetic Interactions between CCN2 and CCN3 behind Their Yin-Yang Collaboration.International journal of molecular sciences · 2022Review
- Multifunctional regulatory protein connective tissue growth factor (CTGF): A potential therapeutic target for diverse diseases.Acta pharmaceutica Sinica. B · 2022Review
- Single Cell RNA Sequencing Reveals Critical Functions ofFrontiers in cell and developmental biology · 2022Article
- CTGF Promotes the Osteoblast Differentiation of Human Periodontal Ligament Stem Cells by Positively Regulating BMP2/Smad Signal Transduction.BioMed research international · 2022Article
- Role of periostin in ECRS.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Review
- CTGF Attenuates Tendon-Derived Stem/Progenitor Cell Aging.Stem cells international · 2019Article
- Periostin as a novel biomarker for postoperative recurrence of chronic rhinosinitis with nasal polyps.Scientific reports · 2018Article
- Effect of FGF-2, TGF-β-1, and BMPs on Teno/Ligamentogenesis and Osteo/Cementogenesis of Human Periodontal Ligament Stem Cells.Molecules and cells · 2017Article
- Effect of Simulated Microgravity Conditions on Differentiation of Adipose Derived Stem Cells towards Fibroblasts Using Connective Tissue Growth Factor.Iranian journal of biotechnology · 2017Article
- CCN2 Expression by Tumor Stroma Is Required for Melanoma Metastasis.The Journal of investigative dermatology · 2015Article
- Combinatorial fibronectin and laminin signaling promote highly efficient cardiac differentiation of human embryonic stem cells.BioResearch open access · 2014Article
- Histamine contributes to tissue remodeling via periostin expression.The Journal of investigative dermatology · 2014Article
- CCN2: a master regulator of the genesis of bone and cartilage.Journal of cell communication and signaling · 2013Article
- Connective tissue growth factor production by activated pancreatic stellate cells in mouse alcoholic chronic pancreatitis.Laboratory investigation; a journal of technical methods and pathology · 2010Article
- The many facets of the matricelluar protein periostin during cardiac development, remodeling, and pathophysiology.Journal of cell communication and signaling · 2009Article
- Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis.Molecular endocrinology (Baltimore, Md.) · 2009Article
- CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes.Journal of cell communication and signaling · 2007Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCCN2/CTGF is known to be involved in tooth germ development and periodontal tissue remodeling, as well as in mesenchymal tissue development and regeneration. In this present study, we investigated the roles of CCN2/CTGF in the proliferation and differentiation of periodontal ligament cells (murine periodontal ligament-derived cell line: MPL) in vitro.
resultsIn cell cultures of MPL, the mRNA expression of the CCN2/CTGF gene was stronger in sparse cultures than in confluent ones and was significantly enhanced by TGF-beta. The addition of recombinant CCN2/CTGF (rCCN2) to MPL cultures stimulated DNA synthesis and cell growth in a dose-dependent manner. Moreover, rCCN2 addition also enhanced the mRNA expression of alkaline phosphatase (ALPase), type I collagen, and periostin, the latter of which is considered to be a specific marker of the periosteum and periodontium; whereas it showed little effect on the mRNA expression of typical osteoblastic markers, e.g., osteopontin and osteocalcin. Finally, rCCN2/CTGF also stimulated ALPase activity and collagen synthesis.
conclusionThese results taken together suggest important roles of CCN2/CTGF in the development and regeneration of periodontal tissue including the periodontal ligament.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.