Evidence map›Paper›PMID 16207341›Full record

ArticleArthritis research & therapy2005

Reconstitution of the adult B cell repertoire after treatment with rituximab.

Iñaki Sanz, Jennifer Anolik

Abstract readComparative StudyComment
In one paragraph

Article in Arthritis research & therapy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Targeted biologic approaches to the treatment of systemic vasculitis.Clinical reviews in allergy & immunology · 2008
    Review
  5. Article
  6. B cell modulation in rheumatology.Current opinion in pharmacology · 2007
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Iñaki SanzDivision of Clinical Immunology & Rheumatology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA. Ignacio_Sanz@urmc.rochester.edu
Jennifer Anolik

Funding

Translational Research Project Effector and Regulatory B cells in SLEU19AI056390 · NIAID · UNIVERSITY OF ROCHESTER · PI LOONEY, RICHARD JOHN · 2003 to 2013
$8.9M
A Model System for the Study of Human B-cell ToleranceR01AI049660 · NIAID · UNIVERSITY OF ROCHESTER · PI SANZ, IGNACIO E. · 2003 to 2007
$1.6M
B cell functional and signaling abnormalities in SLEK08AR048303 · NIAMS · UNIVERSITY OF ROCHESTER · PI ANOLIK, JENNIFER HOWITT · 2002 to 2006
$473k
NIAID NIH HHS R01 AI049660NIAID NIH HHS R01 AI049660-01A1NIAID NIH HHS U19 AI056390NIAID NIH HHS U19-AI56390NIAMS NIH HHS K08 AR048303NIAMS NIH HHS K08AR048303
6 · The paper itself

Abstract

B cells play diverse and fundamental roles in the pathogenesis of autoimmune diseases. Consequently, therapeutic targeting of B cells is gaining prominence in our clinical armamentarium for an ever expanding array of autoimmune and neoplastic disorders. Therefore, it is of great importance to understand the mechanism of action of B cell depletion. Given that the ideal consequence of B cell depletion would be the subsequent re-establishment of immunologic tolerance, a detailed analysis of the properties of the emerging repertoire will be required. The results presented by Rouzière and coworkers in their study of rheumatoid arthritis patients shed some light on this question and are discussed in this commentary.

Indexed as

AdultAntibodies, MonoclonalAntibodies, Monoclonal, Murine-DerivedAntigens, CD19Arthritis, RheumatoidAutoimmune DiseasesB-Lymphocyte SubsetsGene Rearrangement, B-Lymphocyte, Heavy ChainHematopoiesisHumansImmunoglobulin GImmunoglobulin MImmunophenotypingLymphocyte DepletionPolymerase Chain ReactionRituximabAntibodies, MonoclonalAntibodies, Monoclonal, Murine-DerivedAntigens, CD19Immunoglobulin GImmunoglobulin MRituximabTumor Necrosis Factor Receptor Superfamily, Member 7

Identifiers

PMID16207341
PMCPMC1257443

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.