ArticleNucleic acids research1992
Characterization of the testes-specific pim-1 transcript in rat.
Article in Nucleic acids research, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 38 citations in OpenAlex.
- Why target PIM1 for cancer diagnosis and treatment?Future oncology (London, England) · 2010Review
- Loss of MicroRNA targets in the 3' untranslated region as a mechanism of retroviral insertional activation of growth factor independence 1.Journal of virology · 2009Article
- Polyadenylation proteins CstF-64 and tauCstF-64 exhibit differential binding affinities for RNA polymers.The Biochemical journal · 2007Article
- Article
- Developmental expression of pim kinases suggests functions also outside of the hematopoietic system.Oncogene · 2000Article
- Pim kinase expression is induced by LTP stimulation and required for the consolidation of enduring LTP.The EMBO journal · 1999Article
- Two distinct forms of the 64,000 Mr protein of the cleavage stimulation factor are expressed in mouse male germ cells.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice.Molecular and cellular biology · 1995Article
- Pim-1 levels determine the size of early B lymphoid compartments in bone marrow.The Journal of experimental medicine · 1993Article
- In vivo analysis of Pim-1 deficiency.Nucleic acids research · 1993Article
- New nucleotide sequence data on the EMBL File Server.Nucleic acids research · 1992Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pim-1 proto-oncogene encodes a serine/threonine protein kinase and is expressed in cells of hematolymphoid origin and in the germ cell lineages. In somatic cells, the pim-1 gene is expressed as a 2.8 kb transcript while a shorter sized transcript (2.3 kb) is expressed in rat testes. We have determined that the shorter testes-specific pim-1 transcript arises through the use of an alternate polyadenylation signal present in the 3' untranslated region of the gene. This alternate polyadenylation event results in the removal of an A/U-rich regulatory element located in the 3' untranslated region of the pim-1 gene. This A/U-rich motif has been shown by a number of laboratories to destabilize the transcripts of genes that contain this sequence. Consistent with these findings, we have demonstrated that the shortened testes-specific pim-1 transcript is more stable than the longer A/U-rich containing somatic transcript. We suggest that the functional significance of different sized pim-1 transcripts may be directly related to their different stabilities and that the greater stability of the testes-specific transcript may be essential for the translational delay observed in post-meiotic male germ cells.
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