Evidence map›Paper›PMID 16206070›Full record

ArticleThe Journal of infectious diseases2005

Presence of hepatitis C virus (HCV) RNA in the genital tracts of HCV/HIV-1-coinfected women.

Marek J Nowicki, Tomasz Laskus, Georgia Nikolopoulou, Marek Radkowski, Jeffrey Wilkinson, Wenbo B Du, Jorge Rakela, Andrea Kovacs

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 32 citations in OpenAlex.

  1. The vaginal eukaryotic DNA virome and preterm birth.American journal of obstetrics and gynecology · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Marek J NowickiMaternal-Child and Adolescent Center for Infectious Diseases and Virology, University of Southern California, Los Angeles 90033, and Mayo Clinic, Scottsdale, USA. marek@usc.edu
Tomasz Laskus
Georgia Nikolopoulou
Marek Radkowski
Jeffrey Wilkinson
Wenbo B Du
Jorge Rakela
Andrea Kovacs
Mayo Clinic in Arizona · USUniversity of Southern California · USSt. Joseph's Hospital and Medical Center · US

Funding

Women's Interagency HIV Study (WIHS-V)U01AI035004 · NIAID · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI ANASTOS, KATHRYN M., SHARMA, ANJALI · 1993 to 2018
$65.7M
WOMEN'S INTERAGENCY HIV STUDY ORGANIZATION, MANAGEMENT AND COMMUNICATIONSU01AI034989 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, GREENBLATT, RUTH MARTHA · 1993 to 2018
$65.6M
Women's Interagency HIV Study (WIHS) IIIU01AI031834 · NIAID · SUNY DOWNSTATE MEDICAL CENTER · PI GUSTAFSON, DEBORAH R., MINKOFF, HOWARD · 1998 to 2018
$53.5M
WOMEN'S INTERAGENCY HIV STUDY (WIHS) ORGANIZATION AND MANAGEMENTU01AI034994 · NIAID · GEORGETOWN UNIVERSITY · PI KASSAYE, SEBLE G · 1993 to 2018
$52.0M
Women's Interagency HIV Study (WIHS) IV, Chicago ConsortiumU01AI034993 · NIAID · HEKTOEN INSTITUTE FOR MEDICAL RESEARCH · PI COHEN, MARDGE H, FRENCH, AUDREY · 1994 to 2018
$51.0M
WOMENS INTERAGENCY HIV STUDY (WIHS)U01HD032632 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MILAM, JOEL E · 1994 to 2012
$42.0M
WIHS DATA MANAGEMENT AND ANALYSIS CENTER(WDMAC)U01AI042590 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GANGE, STEPHEN J, GOLUB, ELIZABETH T · 1998 to 2018
$38.4M
ZD1839 FOR MALIGNANT ASTROCYTOMA OR GLIOBLASTOMA AND MENINGIOMAM01RR000079 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KESSLER, DAVID A · 1985 to 2006
$26.0M
WELFARE REFORM AND THE PERINATAL HEALTH OF IMMIGRANTSM01RR000083 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KESSLER, DAVID A · 1985 to 2006
$21.1M
HCV and Progression of HIV and HAART Response in WomenR01AI052065 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KOVACS, ANDREA A.Z. · 2002 to 2011
$6.9M
HEPATITIS C VIRUS COINFECTION IN HIV-1 INFECTED SUBJECTSR01DA013760 · NIDA · MAYO CLINIC COLL OF MED, MAYO CLINIC AZ · PI RAKELA, JORGE X · 2000 to 2002
$1.0M
HIV AND HCV DISEASE PROGRESSION IN WOMEN ON HAARTR56AI052065 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KOVACS, ANDREA A.Z. · 2014 to 2014
$655k
NCRR NIH HHS M01 RR000079NCRR NIH HHS M01 RR000083NCRR NIH HHS M01-RR00079NCRR NIH HHS M01-RR00083NIAID NIH HHS R01 AI052065NIAID NIH HHS R01AI52065-01NIAID NIH HHS R56 AI052065NIAID NIH HHS U01 AI031834NIAID NIH HHS U01 AI034989NIAID NIH HHS U01 AI034993NIAID NIH HHS U01 AI034994NIAID NIH HHS U01 AI035004NIAID NIH HHS U01 AI042590NIAID NIH HHS U01-AI-31834NIAID NIH HHS U01-AI-34989NIAID NIH HHS U01-AI-34993NIAID NIH HHS U01-AI-34994NIAID NIH HHS U01-AI-35004NIAID NIH HHS U01-AI-42590NICHD NIH HHS U01 HD032632NICHD NIH HHS U01-HD-32632NIDA NIH HHS DA13760PHS HHS R01 A13760-01
6 · The paper itself

Abstract

backgroundHepatitis C virus (HCV)-infected women--in particular, those coinfected with human immunodeficiency virus type 1 (HIV-1)--can transmit infection to their children and sex partners.

methodsThe present study was conducted to analyze the presence of HCV RNA in cervicovaginal lavage (CVL) fluid from 71 women (58 HCV/HIV-1-coinfected women and 13 HCV-infected, HIV-1-uninfected women) enrolled in the Women's Interagency HIV Study.

resultsHCV RNA was detected (by a commercial polymerase chain reaction assay) in CVL fluid from 18 (29%) of the HIV-1-infected women and from none of the HIV-1-uninfected women (P<.05). Multivariate analysis revealed that risk factors for the presence of HCV RNA in CVL fluid were HCV viremia (odds ratio [OR], 16.81; P=.02) and HIV-1 RNA in CVL fluid (OR, 19.87; P=.02). This observation suggests local interactions between HIV-1 and HCV in the genital tract compartment. There was no correlation between HCV RNA in CVL fluid and CD4, CD8, or CD3 cell counts, HIV-1 RNA viremia, the number of leukocytes in CVL fluid, or HIV-1 therapy. Furthermore, in 3 of 5 analyzed patients who had a detectable CVL HCV RNA load, we found viral variants differing in the 5' untranslated region that were present neither in plasma nor in peripheral-blood mononuclear cells.

conclusionsOur observations point to the importance of the genital tract compartment, in which local HCV replication could be facilitated by local HIV-1 replication.

Indexed as

5' Untranslated RegionsAdultBase SequenceCervix UteriFemaleHepacivirusHepatitis CHIV-1HIV InfectionsHumansLeukocytes, MononuclearMolecular Sequence DataPlasmaPolymerase Chain ReactionReagent Kits, DiagnosticRNA, Viral5' Untranslated RegionsReagent Kits, DiagnosticRNA, Viral

Identifiers

PMID16206070
PMCPMC3164119
OpenAlexW2105595821

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.