ArticleJournal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology2006
Embryonic electrical connections appear to pre-figure a behavioral circuit in the leech CNS.
Article in Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Understanding the Molecular and Cell Biological Mechanisms of Electrical Synapse Formation.Frontiers in neuroanatomy · 2020Article
- Gap Junction Channels of Innexins and Connexins: Relations and Computational Perspectives.International journal of molecular sciences · 2019Review
- Patterns and distribution of presynaptic and postsynaptic elements within serial electron microscopic reconstructions of neuronal arbors from the medicinal leech Hirudo verbana.The Journal of comparative neurology · 2016Article
- Differing synaptic strengths between homologous mechanosensory neurons.Invertebrate neuroscience : IN · 2014Article
- Electrical synapses and their functional interactions with chemical synapses.Nature reviews. Neuroscience · 2014Review
- Regional and segmental differences in the embryonic expression of a putative leech Hox gene, Lox2, by central neurons immunoreactive to FMRFamide-like neuropeptides.Invertebrate neuroscience : IN · 2014Article
- Abundance of gap junctions at glutamatergic mixed synapses in adult Mosquitofish spinal cord neurons.Frontiers in neural circuits · 2014Article
- Ectopic expression of select innexins in individual central neurons couples them to pre-existing neuronal or glial networks that express the same innexin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- The medicinal leech genome encodes 21 innexin genes: different combinations are expressed by identified central neurons.Development genes and evolution · 2012Article
- Regulation and restoration of motoneuronal synaptic transmission during neuromuscular regeneration in the pulmonate snail Helisoma trivolvis.The Biological bulletin · 2011Article
- A male poecillid's sexually dimorphic body plan, behavior, and nervous system.Integrative and comparative biology · 2010Article
- Gap junction expression is required for normal chemical synapse formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Transient electrical coupling regulates formation of neuronal networks.Brain research · 2007Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
During development, many embryos show electrical coupling among neurons that is spatially and temporally regulated. For example, in vertebrate embryos extensive dye coupling is seen during the period of circuit formation, suggesting that electrical connections could pre-figure circuits, but it has been difficult to identify which neuronal types are coupled. We have used the leech Hirudo medicinalis to follow the development of electrical connections within the circuit that produces local bending. This circuit consists of three layers of neurons: four mechanosensory neurons (P cells), 17 identified interneurons, and approximately 24 excitatory and inhibitory motor neurons. These neurons can be identified in embryos, and we followed the spatial and temporal dynamics as specific connections developed. Injecting Neurobiotin into identified cells of the circuit revealed that electrical connections were established within this circuit in a precise manner from the beginning. Connections first appeared between motor neurons; mechanosensory neurons and interneurons started to connect at least a day later. This timing correlates with the development of behaviors, so the pattern of emerging connectivity could explain the appearance first of spontaneous behaviors (driven by a electrically coupled motor network) and then of evoked behaviors (when sensory neurons and interneurons are added to the circuit).
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