Trial reportGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2006
First experiences with high-density silicone oil (Densiron) as an intraocular tamponade in complex retinal detachment.
Trial report in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00403702 (Comparison of Two High-Density Silicone Oils in Complicated Rhegmatogenous Retinal Detachment), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Two High-Density Silicone Oils in Complicated Rhegmatogenous Retinal Detachment
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Heavy and standard silicone oil: intraocular inflammation.International ophthalmology · 2018Pooled it
- Long-term outcomes of Oxane Hd as intraocular tamponade in the treatment of complicated retinal detachment.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2010Trial
- An analysis of heavy silicone oil treatment for inferior proliferative vitreoretinopathy.BMC ophthalmology · 2025Article
- Heavy silicone oil tamponade: a multicentre experience.BMJ open ophthalmology · 2022Article
- Evaluation of long-term outcomes associated with extended heavy-silicone oil use for the treatment of inferior retinal detachment.Scientific reports · 2022Article
- Heavy Silicone Oil as an Endotamponade in Recurrent or Complicated Retinal Detachment and Macular HoleTurkish journal of ophthalmology · 2022Article
- Medical management of silicone oil associated acute postoperative ocular inflammation.BMJ case reports · 2021Article
- Outcome of pediatric retinal detachment using high-density silicone oil.International ophthalmology · 2021Article
- Long-Term Safety and Efficacy of Siluron2000 with Pars Plana Vitrectomy in the Treatment of Patients with Severe Vitreoretinopathy and Chronic Macular Holes.Clinical ophthalmology (Auckland, N.Z.) · 2021Article
- Intraocular Pressure Rise Linked to Silicone Oil in Retinal Surgery: A Review.Vision (Basel, Switzerland) · 2020Review
- Comparative Biochemical Outcomes, Effectiveness and Tolerance of Densiron 68 and Oxane HD for the Management of Complicated Retinal DetachmentTurkish journal of ophthalmology · 2019Article
- Advances in the treatment of rhegmatogenous retinal detachment.International journal of ophthalmology · 2019Review
- Densiron 68 heavy silicone oil in the management of inferior retinal detachment recurrence: analysis on functional and anatomical outcomes and complications.International journal of ophthalmology · 2019Article
- Vitrectomy with scleral buckling versus with inferior retinectomy in treating primary rhegmatogenous retinal detachment with PVR and inferior breaks.Eye (London, England) · 2018Article
- Inflammation induced by perfluorocarbon liquid: intra- and postoperative use.BioMed research international · 2014Review
- Heavy silicone oil and intraocular inflammation.BioMed research international · 2014Review
- Vitreous substitutes: the present and the future.BioMed research international · 2014Review
- Clinical observations and occurrence of complications following heavy silicone oil surgery.BioMed research international · 2014Article
- Heavy silicone oil as a long-term endotamponade agent for complicated retinal detachments.BioMed research international · 2014Article
- Anatomical and functional outcomes after Densiron 68 heavy silicone oil tamponade for complicated retinal detachment in Chinese eyes.International journal of ophthalmology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn this study, we evaluated the anatomic and functional outcome and intraocular adverse effects after a 3-month endotamponade with Densiron 68, a mixture of F(6)H(8) with silicone oil, in complex inferior re-detachments.
methodsForty-eight eyes of 48 patients aged 27-82 years with retinal re-detachment due to proliferative vitreoretinopathy (PVR) grades CP1 to CA7 were included. Mean duration of the Densiron endotamponade was 108.7+/-66.9 days, with a mean follow-up after removal of 102.8+/-31.9 days.
resultsTwenty-two patients (45.8%) showed stable retinal reattachment after Densiron removal. Fourteen patients (29.2%) developed retinal re-detachment after removal, generally within 1 month and in the upper circumference (n=8). In 11 patients (22.9%) recurrent re-detachment (inferior n=8) appeared during Densiron endotamponade. In one eye (2.1%) treatment was primarily unsuccessful. Visual acuity improved from mean logMAR 1.66+/-1.03 to 1.47+/-0.97 (not statistically significant, P=0.257). Side effects included temporary inflammatory reaction (n=10), fibrin accumulation (n=6), sterile hypopyon (n=2), vitreous hemorrhage (n=6), elevated IOP (n=5), emulsification (n=4) and chronic hypotony (n=4).
conclusionThe anatomical success rate without further interventions of 45.8% (22 of 48 patients) seems unsatisfactory. However, in evaluating the potential of Densiron, it should be considered that all patients in this study had previous surgery with standard procedures, including silicone oil, which had already failed. Intraoperative laser photocoagulation of the periphery of the upper quadrants might reduce the risk of retinal re-detachments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.