ArticleJournal of human genetics2005
Lack of association of histamine-N-methyltransferase (HNMT) polymorphisms with asthma in the Indian population.
Article in Journal of human genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 27 citations in OpenAlex.
- HistamineInternational journal of molecular sciences · 2019Review
- Genetic Variation along the Histamine Pathway in Children with Allergic versus Nonallergic Asthma.American journal of respiratory cell and molecular biology · 2015Article
- Genetic variation within the histamine pathway among patients with asthma--a pilot study.The Journal of asthma : official journal of the Association for the Care of Asthma · 2015Article
- Involvement of human histamine N-methyltransferase gene polymorphisms in susceptibility to atopic dermatitis in korean children.Allergy, asthma & immunology research · 2012Article
- Polymorphisms of two histamine-metabolizing enzymes genes and childhood allergic asthma: a case control study.Clinical and molecular allergy : CMA · 2010Article
- The histamine N-methyltransferase T105I polymorphism affects active site structure and dynamics.Biochemistry · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histamine plays a major role in allergic disorders, including asthma. A major pathway of histamine biotransformation in the lungs is mediated by histamine N-methyltransferase (HNMT). We investigated the association of a functional SNP C314T; a SNP A929G, a (CA)n repeat in intron 5, and a novel (CA)n repeat (BV677277), 7.5 kb downstream of the HNMT gene with asthma and its associated traits such as total serum IgE levels in a case-control as well as in a family-based study design. In contrast to a previous study, no association was observed for the polymorphisms investigated with asthma (P>0.05). When haplotypes were constructed for these loci and compared, no significant difference was observed in the distribution between cases and controls. In the family-based design, no biased transmission was observed for any of the polymorphisms and haplotypes with asthma using the additive model of inheritance in family-based association test (FBAT). Thus, consistent with the case-control findings, the polymorphisms and haplotypes in the HNMT gene are not associated with asthma in the Indian population.
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Registered trials
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