ArticleMolecular psychiatry2006
A genome-wide search for alleles and haplotypes associated with autism and related pervasive developmental disorders on the Faroe Islands.
Article in Molecular psychiatry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- The oxytocin receptor gene (OXTR) is associated with autism spectrum disorder: a meta-analysis.Molecular psychiatry · 2015Pooled it
- Glutamatergic candidate genes in autism spectrum disorder: an overview.Journal of neural transmission (Vienna, Austria : 1996) · 2014Pooled it
- Exploring key genes and pathways associated with sex differences in autism spectrum disorder: integrated bioinformatic analysis.Mammalian genome : official journal of the International Mammalian Genome Society · 2024Article
- Family-Based Genome-Wide Association Study of Autism Spectrum Disorder in Middle Eastern Families.Genes · 2021Article
- Both rare and common genetic variants contribute to autism in the Faroe Islands.NPJ genomic medicine · 2019Article
- Serum Oxytocin Levels and an Oxytocin Receptor Gene Polymorphism (rs2254298) Indicate Social Deficits in Children and Adolescents with Autism Spectrum Disorders.Frontiers in neuroscience · 2017Article
- A genome-wide screen for acrophobia susceptibility loci in a Finnish isolate.Scientific reports · 2016Article
- Comparative two-dimensional polyacrylamide gel electrophoresis of the salivary proteome of children with autism spectrum disorder.Journal of cellular and molecular medicine · 2015Article
- Variants of the CNTNAP2 5' promoter as risk factors for autism spectrum disorders: a genetic and functional approach.Molecular psychiatry · 2015Article
- High-resolution chromosome ideogram representation of currently recognized genes for autism spectrum disorders.International journal of molecular sciences · 2015Article
- Plasma oxytocin concentrations and OXTR polymorphisms predict social impairments in children with and without autism spectrum disorder.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Redefining autism spectrum disorder using DSM-5: the implications of the proposed DSM-5 criteria for autism spectrum disorders.Journal of autism and developmental disorders · 2014Article
- Mosaic epigenetic dysregulation of ectodermal cells in autism spectrum disorder.PLoS genetics · 2014Article
- Shedding heat on oxytocin.Endocrinology · 2013Article
- Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder.Molecular autism · 2013Article
- The evidence for association of ATP2B2 polymorphisms with autism in Chinese Han population.PloS one · 2013Article
- Brain region-specific altered expression and association of mitochondria-related genes in autism.Molecular autism · 2012Article
- A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder.Human genetics · 2012Article
- The oxytocin system in drug discovery for autism: animal models and novel therapeutic strategies.Hormones and behavior · 2012Review
- The effects of birth order and birth interval on the phenotypic expression of autism spectrum disorder.PloS one · 2012Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The involvement of genetic factors in the etiology of autism has been clearly established. We undertook a genome-wide search for regions containing susceptibility genes for autism in 12 subjects with childhood autism and related pervasive developmental disorders (PDDs) and 44 controls from the relatively isolated population of the Faroe Islands. In total, 601 microsatellite markers distributed throughout the human genome with an average distance of 5.80 cM were genotyped, including 502 markers in the initial scan. The Faroese population structure and genetic relatedness of cases and controls were also evaluated. Based on a combined approach, including an assumption-free test as implemented in CLUMP, Fisher's exact test for specific alleles and haplotypes, and IBD(0) probability calculations, we found association between autism and microsatellite markers in regions on 2q, 3p, 6q, 15q, 16p, and 18q. The most significant finding was on 3p25.3 (P(T1)=0.00003 and P(T4)=0.00007), which was also supported by other genetic studies. Furthermore, no evidence of population substructure was found, and a higher degree of relatedness among cases could not be detected, decreasing the risk of inflated P-values. Our data suggest that markers in these regions are in linkage disequilibrium with genes involved in the etiology of autism, and we hypothesize susceptibility genes for autism and related PDDs to be localized within these regions.
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