ArticleOncogene2006
TRF2 inhibition promotes anchorage-independent growth of telomerase-positive human fibroblasts.
Article in Oncogene, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- A survey of chromosomal instability measures across mechanistic models.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A survey of CIN measures across mechanistic models.bioRxiv : the preprint server for biology · 2023Article
- SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage.Nucleic acids research · 2017Article
- DNA damage and the balance between survival and death in cancer biology.Nature reviews. Cancer · 2016Review
- The basic N-terminal domain of TRF2 limits recombination endonuclease action at human telomeres.Cell cycle (Georgetown, Tex.) · 2014Article
- G-quadruplexes as potential therapeutic targets for embryonal tumors.Molecules (Basel, Switzerland) · 2013Review
- TRF2 controls telomeric nucleosome organization in a cell cycle phase-dependent manner.PloS one · 2012Article
- PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy.Oncogene · 2010Article
- Platination of telomeric DNA by cisplatin disrupts recognition by TRF2 and TRF1.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2010Article
- Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway.Nucleic acids research · 2009Article
- Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect.The Journal of clinical investigation · 2007Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although telomere instability is observed in human tumors and is associated with the development of cancers in mice, it has yet to be established that it can contribute to the malignant transformation of human cells. We show here that in checkpoint-compromised telomerase-positive human fibroblasts an episode of TRF2 inhibition promotes heritable changes that increase the ability to grow in soft agar, but not tumor growth in nude mice. This transforming activity is associated to a burst of telomere instability but is independent of an altered control of telomere length. Moreover, it cannot be recapitulated by an increase in chromosome breaks induced by an exposure to gamma-radiations. Since it can be revealed in the context of telomerase-proficient human cells, telomere dysfunction might contribute to cancer progression even at late stages of the oncogenesis process, after the telomerase reactivation step.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.