ArticleOncogene2006
Bovine papillomavirus E5 oncoprotein binds to the activated form of the platelet-derived growth factor beta receptor in naturally occurring bovine urinary bladder tumours.
Article in Oncogene, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 65 citations in OpenAlex.
- Molecular findings and virological assessment of bladder papillomavirus infection in cattle.The veterinary quarterly · 2024Article
- Characterization of Episomal Replication of Bovine Papillomavirus Type 1 DNA in Long-Term Virion-Infected Saccharomyces Cerevisiae Culture.Virologica Sinica · 2021Article
- BovineFrontiers in immunology · 2021Article
- Anogenital-Associated Papillomaviruses in Animals: Focusing onPathogens (Basel, Switzerland) · 2020Review
- Bovine Papillomavirus Type 2 Infection Associated with Papillomatosis of the Amniotic Membrane in Water Buffaloes (Pathogens (Basel, Switzerland) · 2020Article
- Article
- The E5 proteins.Virology · 2013Review
- BAG3 protects bovine papillomavirus type 1-transformed equine fibroblasts against pro-death signals.Veterinary research · 2013Article
- Bovine papillomavirus on the scene of crime: is E5 oncogene the only guilty party?Infectious agents and cancer · 2013Article
- Bovine papillomavirus E5 and E7 oncoproteins in naturally occurring tumors: are two better than one?Infectious agents and cancer · 2013Article
- Bovine papillomavirus type 2 infection and a series of mesenchymal tumors of the urinary bladder in cattle.BioMed research international · 2013Article
- Article
- Bovine papillomavirus type 2 infection and microscopic patterns of urothelial tumors of the urinary bladder in water buffaloes.BioMed research international · 2013Article
- Analysis of activated platelet-derived growth factor β receptor and Ras-MAP kinase pathway in equine sarcoid fibroblasts.BioMed research international · 2013Article
- Molecular and epigenetic analysis of the fragile histidine triad tumour suppressor gene in equine sarcoids.BMC veterinary research · 2012Article
- Productive infection of bovine papillomavirus type 2 in the placenta of pregnant cows affected with urinary bladder tumors.PloS one · 2012Article
- Calpain3 is expressed in a proteolitically active form in papillomavirus-associated urothelial tumors of the urinary bladder in cattle.PloS one · 2010Article
- Human papillomavirus type 16 E5 protein as a therapeutic target.Yonsei medical journal · 2006Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies regarding the functions of the bovine papillomavirus (BPV) E5 oncoprotein in vivo are lacking and no E5-mediated mechanism underlying epithelial carcinogenesis is known. We have shown that BPV-2 DNA is present in the majority of naturally occurring urinary bladder tumours of cattle and that E5 is expressed in the cancer cells. Here we show that the interaction between the platelet-derived growth factor (PDGF) beta receptor and BPV E5, described in vitro in cultured cells, takes place in vivo in bovine urinary bladder cancers. In these cancers, E5 and PDGF beta receptor colocalize, as shown by confocal microscopy, and physically interact, as shown by coimmunoprecipitation. Furthermore, the PDGF beta receptor associated with E5 is highly phosphorylated, suggesting the functional activation of the receptor upon E5 interaction. Our results demonstrate, for the first time, that E5-PDGF beta receptor interaction occurs during the natural history of bovine urinary bladder tumours, suggesting an important role for E5 in carcinogenesis. Finally, the system provides a suitable animal model of papillomavirus-associated cancer to test therapeutic vaccination against E5. Successful bladder tumour regression would provide a valuable model for therapeutic vaccination against papillomavirus-associated tumours.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.