ArticleApplied and environmental microbiology2005
Genetic and transcriptional organization of the clpC locus in Bifidobacterium breve UCC 2003.
Article in Applied and environmental microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Stress Response in Bifidobacteria.Microbiology and molecular biology reviews : MMBR · 2022Review
- Genome-Wide Assessment of Stress-Associated Genes in Bifidobacteria.Applied and environmental microbiology · 2022Article
- Global transcriptional landscape and promoter mapping of the gut commensal Bifidobacterium breve UCC2003.BMC genomics · 2017Article
- Molecular characterization of three Lactobacillus delbrueckii subsp. bulgaricus phages.Applied and environmental microbiology · 2014Article
- A bile-inducible membrane protein mediates bifidobacterial bile resistance.Microbial biotechnology · 2012Article
- Global genome transcription profiling of Bifidobacterium bifidum PRL2010 under in vitro conditions and identification of reference genes for quantitative real-time PCR.Applied and environmental microbiology · 2011Article
- Enhancing the stress responses of probiotics for a lifestyle from gut to product and back again.Microbial cell factories · 2011Review
- How do bifidobacteria counteract environmental challenges? Mechanisms involved and physiological consequences.Genes & nutrition · 2011Article
- Genomic insights into bifidobacteria.Microbiology and molecular biology reviews : MMBR · 2010Review
- An interactive regulatory network controls stress response in Bifidobacterium breve UCC2003.Journal of bacteriology · 2009Article
- Exploring the diversity of the bifidobacterial population in the human intestinal tract.Applied and environmental microbiology · 2009Article
- Molecular characterization of hsp20, encoding a small heat shock protein of bifidobacterium breve UCC2003.Applied and environmental microbiology · 2007Article
- Genetic characterization of the Bifidobacterium breve UCC 2003 hrcA locus.Applied and environmental microbiology · 2005Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A homolog of the clpC ATPase gene was identified in the genome of Bifidobacterium breve UCC 2003. Since this gene is very well conserved among eubacteria, we employed a PCR-based approach using primers based on highly conserved regions of ClpC proteins in order to identify homologous genes in other bifidobacterial species. Analysis by slot blot, Northern blot, and primer extension experiments showed that transcription of clpC is induced in response to moderate heat shock regimes. Moreover, we identified in the genome sequence of B. breve UCC 2003 a gene, designated clgR, which is predicted to encode a transcriptional regulator involved in regulation of the bifidobacterial clpC gene. The role of this protein in the regulation of B. breve UCC 2003 clpC gene expression was investigated by performing gel retardation experiments. We show that a biologically active ClgR molecule requires one or more proteinaceous coactivators to assist in the specific binding of ClgR to the clpC promoter region.
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