ArticleApplied and environmental microbiology2005
Alternative lactose catabolic pathway in Lactococcus lactis IL1403.
Article in Applied and environmental microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Optimizing dark fermentation for hydrogen production: lessons fromFrontiers in microbiology · 2026Article
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- Polar-Region Soils as Novel Reservoir of Lactic Acid Bacteria from the GenusInternational journal of molecular sciences · 2024Article
- The Presence of Plasmids inInternational journal of molecular sciences · 2023Article
- Cross-utilization of β-galactosides and cellobiose inThe Journal of biological chemistry · 2020Article
- GlaR (YugA)-a novel RpiR-family transcription activator of the Leloir pathway of galactose utilization in Lactococcus lactis IL1403.MicrobiologyOpen · 2019Article
- Presence of galactose in precultures induces lacS and leads to short lag phase in lactose-grown Lactococcus lactis cultures.Journal of industrial microbiology & biotechnology · 2019Article
- The extracellular loop of Man-PTS subunit IID is responsible for the sensitivity of Lactococcus garvieae to garvicins A, B and C.Scientific reports · 2018Article
- Large plasmidome of dairy Lactococcus lactis subsp. lactis biovar diacetylactis FM03P encodes technological functions and appears highly unstable.BMC genomics · 2018Article
- Preferred Hexoses Influence Long-Term Memory in and Induction of Lactose Catabolism by Streptococcus mutans.Applied and environmental microbiology · 2018Article
- Insights into the Geobacillus stearothermophilus species based on phylogenomic principles.BMC microbiology · 2017Article
- Lactococci of Local Origin as Potential Starter Cultures for Traditional Montenegrin Cheese Production.Food technology and biotechnology · 2017Article
- Article
- A novel cell factory for efficient production of ethanol from dairy waste.Biotechnology for biofuels · 2016Article
- ClaR--a novel key regulator of cellobiose and lactose metabolism in Lactococcus lactis IL1403.Applied microbiology and biotechnology · 2015Article
- The Lcn972 bacteriocin-encoding plasmid pBL1 impairs cellobiose metabolism in Lactococcus lactis.Applied and environmental microbiology · 2011Article
- Towards enhanced galactose utilization by Lactococcus lactis.Applied and environmental microbiology · 2010Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we present a glimpse of the diversity of Lactococcus lactis subsp. lactis IL1403 beta-galactosidase phenotype-negative mutants isolated by negative selection on solid media containing cellobiose or lactose and X-Gal (5-bromo-4-chloro-3-indolyl-beta-d-galactopyranoside), and we identify several genes essential for lactose assimilation. Among these are ccpA (encoding catabolite control protein A), bglS (encoding phospho-beta-glucosidase), and several genes from the Leloir pathway gene cluster encoding proteins presumably essential for lactose metabolism. The functions of these genes were demonstrated by their disruption and testing of the growth of resultant mutants in lactose-containing media. By examining the ccpA and bglS mutants for phospho-beta-galactosidase activity, we showed that expression of bglS is not under strong control of CcpA. Moreover, this analysis revealed that although BglS is homologous to a putative phospho-beta-glucosidase, it also exhibits phospho-beta-galactosidase activity and is the major enzyme in L. lactis IL1403 involved in lactose hydrolysis.
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