ArticleApplied and environmental microbiology2005
Effects of orally administered tetracycline on the intestinal community structure of chickens and on tet determinant carriage by commensal bacteria and Campylobacter jejuni.
Article in Applied and environmental microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 61 citations in OpenAlex.
- Effects ofVeterinary and animal science · 2026Article
- Investigating a propagation of emerging carbapenemase-producing Enterobacteriaceae in Dutch broiler production pyramid through stochastic simulation.One health (Amsterdam, Netherlands) · 2024Article
- Impact of Veterinary Feed Directive Rules Changes on the Prevalence of Antibiotic Resistance Bacteria Isolated from Cecal Samples of Food-Producing Animals at US Slaughterhouses.Pathogens (Basel, Switzerland) · 2024Article
- Assessing the Effect of Oxytetracycline on the Selection of ResistantAntibiotics (Basel, Switzerland) · 2023Article
- Conditions Necessary for the Transfer of Antimicrobial Resistance in Poultry Litter.Antibiotics (Basel, Switzerland) · 2023Article
- Production systems and important antimicrobial resistant-pathogenic bacteria in poultry: a review.Journal of animal science and biotechnology · 2022Review
- Prevalence, Tetracycline Resistance and Tet(O) Gene Identification in PathogenicAntibiotics (Basel, Switzerland) · 2022Article
- Genomic diversity ofMicrobial genomics · 2021Article
- Determination of Chlortetracycline Residues, Antimicrobial Activity and Presence of Resistance Genes in Droppings of Experimentally Treated Broiler Chickens.Molecules (Basel, Switzerland) · 2018Article
- Successional changes in the chicken cecal microbiome during 42 days of growth are independent of organic acid feed additives.BMC veterinary research · 2014Article
- Identification of diarrheagenic Escherichia coli strains from avian organic fertilizers.International journal of environmental research and public health · 2014Article
- Perspectives in the use of tannins as alternative to antimicrobial growth promoter factors in poultry.Frontiers in microbiology · 2014Review
- Resistance gene transfer during treatments for experimental avian colibacillosis.Antimicrobial agents and chemotherapy · 2012Article
- Food animals and antimicrobials: impacts on human health.Clinical microbiology reviews · 2011Review
- From structure to function: the ecology of host-associated microbial communities.Microbiology and molecular biology reviews : MMBR · 2010Review
- Turkey fecal microbial community structure and functional gene diversity revealed by 16S rRNA gene and metagenomic sequences.Journal of microbiology (Seoul, Korea) · 2008Article
- Comparative metagenomics reveals host specific metavirulomes and horizontal gene transfer elements in the chicken cecum microbiome.PloS one · 2008Article
- Application of methods for identifying broiler chicken gut bacterial species linked with increased energy metabolism.Applied and environmental microbiology · 2008Article
- Impact of feed supplementation with antimicrobial agents on growth performance of broiler chickens, Clostridium perfringens and enterococcus counts, and antibiotic resistance phenotypes and distribution of antimicrobial resistance determinants in Escherichia coli isolates.Applied and environmental microbiology · 2007Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a growing concern that antibiotic usage in animal production has selected for resistant food-borne bacteria. Since tetracyclines are common therapeutic antibiotics used in poultry production, we sought to evaluate the effects of oral administration on the resistance of poultry commensal bacteria and the intestinal bacterial community structure. The diversity indices calculated from terminal restriction fragment length polymorphism (T-RFLP) analysis of 16S rRNA amplicons did not indicate significant changes in the cecal bacterial community in response to oxytetracycline. To evaluate its effects on cultivable commensals, Enterococcus spp., Escherichia coli, and Campylobacter spp. were isolated from the cecal droppings of broiler chickens. Enterococcus spp. and E. coli expressed tetracycline MICs of >8 microg/ml and harbored a variety of tet resistance determinants regardless of the tetracycline exposure history of the birds. The enterococcal isolates possessed tetM (61%), tetL (25.4%), and tetK (1.3%), as well as tetO (52.5%), the determinant known to confer a tetracycline resistance phenotype in Campylobacter jejuni. E. coli isolates harbored tetA (32.2%) or tetB (30.5%). Tetracycline MICs remained at <2 microg/ml for Campylobacter isolates before and after tetracycline treatment of the chickens, even though isolates expressing MICs of >16 mug/ml were commonly cultured from flocks that did not receive oxytetracycline. The results imply that complex ecological and genetic factors contribute to the prevalence of antibiotic resistance arising from resistance gene transfer in the production environment.
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