ArticleBlood2006
Sox4 cooperates with Evi1 in AKXD-23 myeloid tumors via transactivation of proviral LTR.
Article in Blood, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 47 citations in OpenAlex.
- The oncogenic role of ecotropic viral integration site 1 in hematological malignancies: mechanisms of activation and leukemogenesis.Frontiers in immunology · 2026Review
- Longitudinal genomic profiling of chemotherapy-related CHIP variants in patients with ovarian cancer.Frontiers in oncology · 2025Article
- Activation of human endogenous retroviruses by Sox proteins induces cell apoptosis via the caspase-3 pathway.Frontiers in microbiology · 2025Article
- Zebrafish: a convenient tool for myelopoiesis research.Cell regeneration (London, England) · 2023Review
- SOX4: The unappreciated oncogene.Seminars in cancer biology · 2020Review
- MAT2A as Key Regulator and Therapeutic Target inCancers · 2020Article
- Overexpression of SOX4 correlates with poor prognosis of acute myeloid leukemia and is leukemogenic in zebrafish.Blood cancer journal · 2017Article
- Myeloid differentiation and the leukemia-initiating cell.Leukemia supplements · 2014Article
- The Sox4/Tcf7l1 axis promotes progression of BCR-ABL-positive acute lymphoblastic leukemia.Haematologica · 2014Article
- Sox4 links tumor suppression to accelerated aging in mice by modulating stem cell activation.Cell reports · 2014Article
- Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.PloS one · 2014Article
- Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia.Cancer cell · 2013Article
- The role of SRY-related HMG box transcription factor 4 (SOX4) in tumorigenesis and metastasis: friend or foe?Oncogene · 2013Review
- PML-RARα co-operates with Sox4 in acute myeloid leukemia development in mice.Haematologica · 2013Article
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- Prediction of response to therapy with ezatiostat in lower risk myelodysplastic syndrome.Journal of hematology & oncology · 2012Article
- Clinicopathological significance of SOX4 expression in primary gallbladder carcinoma.Diagnostic pathology · 2012Article
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- Common and overlapping oncogenic pathways contribute to the evolution of acute myeloid leukemias.Cancer research · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Myeloid leukemias in AKXD23 mice contain proviral insertions at Evi1, resulting in transcriptional activation. Although Evi1 is clearly involved in leukemia, gene transfer studies in mice with Evi1 fail to cause leukemia, arguing that cooperating events are necessary. We reanalyzed AKXD-23 tumors for cooperating proviral insertion and found that each tumor had a proviral insertion in Sox4, which encodes an HMG-box transcription factor. RNA analysis revealed these insertions cause increased Sox4 expression. Overexpression of Sox4 in 32Dcl3 cells markedly inhibited cytokine-induced granulocyte maturation, as documented by morphologic and mRNA analysis. Sox4-expressing cells had higher levels of transcripts associated with proliferation, including Evi1. Conversely, in leukemic cells that express Sox4 and bear provirally activated Evi1, suppression of Sox4 with short hairpin RNAs resulted in down-regulation of both Sox4 and Evi1. By cotransfection studies, Sox4 is able to transactivate the AKV long terminal repeat, which likely explains how Sox4 transcriptionally up-regulates provirally activated Evi1; however, Sox4 does not appear to regulate the native Evi1 promoter. We propose that Sox4 proviral activation is selected for in the setting of prior proviral activation of Evi1, because it transactivates the relatively weak LTR of AKV leading to higher Evi1 expression and consequent block to differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.