ArticleGenetics2006
Interaction between hormonal signaling pathways in Drosophila melanogaster as revealed by genetic interaction between methoprene-tolerant and broad-complex.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- Agxt2l-mediated glycerophospholipid metabolism in trophocytes explains Apis mellifera queen's higher oviposition over A. cerana.Communications biology · 2025Article
- Juvenile hormone receptor Methoprene tolerant: Functions and applications.Vitamins and hormones · 2023Article
- Transcriptomic meta-signatures identified in Anopheles gambiae populations reveal previously undetected insecticide resistance mechanisms.Nature communications · 2018Article
- DENR-MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth.Nature · 2014Article
- Juvenile hormone and insulin suppress lipolysis between periods of lactation during tsetse fly pregnancy.Molecular and cellular endocrinology · 2013Article
- Steroid receptor co-activator is required for juvenile hormone signal transduction through a bHLH-PAS transcription factor, methoprene tolerant.The Journal of biological chemistry · 2011Article
- Article
- Epigenetic transgenerational actions of vinclozolin on promoter regions of the sperm epigenome.PloS one · 2010Article
- Tenectin is a novel alphaPS2betaPS integrin ligand required for wing morphogenesis and male genital looping in Drosophila.Developmental biology · 2010Article
- Dissecting the splicing mechanism of the Drosophila editing enzyme; dADAR.Nucleic acids research · 2009Article
- Hormonal regulation of the humoral innate immune response in Drosophila melanogaster.The Journal of experimental biology · 2008Article
- bHLH-PAS family transcription factor methoprene-tolerant plays a key role in JH action in preventing the premature development of adult structures during larval-pupal metamorphosis.Mechanisms of development · 2008Article
- Overexpression of Methoprene-tolerant, a Drosophila melanogaster gene that is critical for juvenile hormone action and insecticide resistance.Insect biochemistry and molecular biology · 2008Article
- Article
- Identification and characterization of a juvenile hormone response element and its binding proteins.The Journal of biological chemistry · 2007Article
- Anciently duplicated Broad Complex exons have distinct temporal functions during tissue morphogenesis.Development genes and evolution · 2007Article
- Juvenile hormone resistance gene Methoprene-tolerant controls entry into metamorphosis in the beetle Tribolium castaneum.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Drosophila melanogaster Methoprene-tolerant (Met) gene homologs from three mosquito species: Members of PAS transcriptional factor family.Journal of insect physiology · 2007Article
- Wide mutational spectrum of a gene involved in hormone action and insecticide resistance in Drosophila melanogaster.Molecular genetics and genomics : MGG · 2006Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Juvenile hormone (JH) regulates insect development by a poorly understood mechanism. Application of JH agonist insecticides to Drosophila melanogaster during the ecdysone-driven onset of metamorphosis results in lethality and specific morphogenetic defects, some of which resemble those in mutants of the ecdysone-regulated Broad-Complex (BR-C). The Methoprene-tolerant (Met) bHLH-PAS gene mediates JH action, and Met mutations protect against the lethality and defects. To explore relationships among these two genes and JH, double mutants were constructed between Met alleles and alleles of each of the BR-C complementation groups: broad (br), reduced bristles on palpus (rbp), and 2Bc. Defects in viability and oogenesis were consistently more severe in rbp Met or br Met double mutants than would be expected if these genes act independently. Additionally, complementation between BR-C mutant alleles often failed when MET was absent. Patterns of BRC protein accumulation during metamorphosis revealed essentially no difference between wild-type and Met-null individuals. JH agonist treatment did not block accumulation of BRC proteins. We propose that MET and BRC interact to control transcription of one or more downstream effector genes, which can be disrupted either by mutations in Met or BR-C or by application of JH/JH agonist, which alters MET interaction with BRC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.