ArticleGenetics2006
Triglyceride pools, flight and activity variation at the Gpdh locus in Drosophila melanogaster.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Energy dissipation via the glycerol phosphate shuttle: coupling glycolysis to mitochondrial thermogenesis in Drosophila melanogaster flight muscle.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- Alternative splicing perspective to prey preference of environmentally friendly biological agent Cryptolaemus montrouzieri.BMC genomics · 2024Article
- The Drosophila melanogaster enzyme glycerol-3-phosphate dehydrogenase 1 is required for oogenesis, embryonic development, and amino acid homeostasis.G3 (Bethesda, Md.) · 2022Article
- Compartmentalization and metabolic regulation of glycolysis.Journal of cell science · 2021Review
- CytochromeCells · 2021Review
- Organ reserve, excess metabolic capacity, and aging.Biogerontology · 2018Review
- Sex and Genetic Background Influence Superoxide Dismutase (cSOD)-Related Phenotypic Variation inG3 (Bethesda, Md.) · 2017Article
- Australian black field crickets show changes in neural gene expression associated with socially-induced morphological, life-history, and behavioral plasticity.BMC genomics · 2016Article
- Genetic perturbation of key central metabolic genes extends lifespan in Drosophila and affects response to dietary restriction.Proceedings. Biological sciences · 2015Article
- Interactions of NADP-reducing enzymes across varying environmental conditions: a model of biological complexity.G3 (Bethesda, Md.) · 2012Article
- Molecular cloning, expression, and immunolocalization of the NAD(+)-dependent glycerol 3-phosphate dehydrogenase (GPD) from Clonorchis sinensis.Parasitology research · 2011Article
- Molecular population genetics and selection in the glycolytic pathway.The Journal of experimental biology · 2011Review
- Experimental approaches to evaluate the contributions of candidate protein-coding mutations to phenotypic evolution.Methods in molecular biology (Clifton, N.J.) · 2011Review
- A model of oxidative stress management: moderation of carbohydrate metabolizing enzymes in SOD1-null Drosophila melanogaster.PloS one · 2011Article
- Article
- Quantifying interactions within the NADP(H) enzyme network in Drosophila melanogaster.Genetics · 2009Article
- Article
- An amino acid polymorphism in the couch potato gene forms the basis for climatic adaptation in Drosophila melanogaster.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Proteome response to the panneural expression of human wild-type alpha-synuclein: a Drosophila model of Parkinson's disease.Journal of proteome research · 2008Article
- Flux control and excess capacity in the enzymes of glycolysis and their relationship to flight metabolism in Drosophila melanogaster.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
We have created a set of P-element excision-derived Gpdh alleles that generate a range of GPDH activity phenotypes ranging from zero to full activity. By placing these synthetic alleles in isogenic backgrounds, we characterize the effects of minor and major activity variation on two different aspects of Gpdh function: the standing triglyceride pool and glycerol-3-phosphate shuttle-assisted flight. We observe small but statistically significant reductions in triglyceride content for adult Gpdh genotypes possessing 33-80% reductions from normal activity. These small differences scale to a notable proportion of the observed genetic variation in triglyceride content in natural populations. Using a tethered fly assay to assess flight metabolism, we observed that genotypes with 100 and 66% activity exhibited no significant difference in wing-beat frequency (WBF), while activity reductions from 60 to 10% showed statistically significant reductions of approximately 7% in WBF. These studies show that the molecular polymorphism associated with GPDH activity could be maintained in natural populations by selection in the triglyceride pool.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.