ArticleGenetics2006
Evidence for a selective sweep in the wapl region of Drosophila melanogaster.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- Drosophila Evolution over Space and Time (DEST): A New Population Genomics Resource.Molecular biology and evolution · 2021Article
- Genomic Analysis of European Drosophila melanogaster Populations Reveals Longitudinal Structure, Continent-Wide Selection, and Previously Unknown DNA Viruses.Molecular biology and evolution · 2020Article
- Population Genomics on the Fly: Recent Advances in Drosophila.Methods in molecular biology (Clifton, N.J.) · 2020Review
- Background selection as null hypothesis in population genomics: insights and challenges fromPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- On the Long-term Stability of Clines in Some Metabolic Genes in Drosophila melanogaster.Scientific reports · 2017Article
- Holding it together: rapid evolution and positive selection in the synaptonemal complex of Drosophila.BMC evolutionary biology · 2016Article
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- Molecular population genetics of the NADPH cytochrome P450 reductase (CPR) gene in Anopheles minimus.Genetica · 2014Article
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- Detecting selective sweeps from pooled next-generation sequencing samples.Molecular biology and evolution · 2012Article
- Genealogical lineage sorting leads to significant, but incorrect Bayesian multilocus inference of population structure.Molecular ecology · 2011Article
- Identification of X-linked quantitative trait loci affecting cold tolerance in Drosophila melanogaster and fine mapping by selective sweep analysis.Molecular ecology · 2011Article
- Molecular population genetics and selection in the glycolytic pathway.The Journal of experimental biology · 2011Review
- Genetic hitchhiking versus background selection: the controversy and its implications.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Molecular diversification in the quorum-sensing system of Vibrio cholerae: Role of natural selection in the emergence of pandemic strains.Applied and environmental microbiology · 2009Article
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- Evidence that strong positive selection drives neofunctionalization in the tandemly duplicated polyhomeotic genes in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Genomewide spatial correspondence between nonsynonymous divergence and neutral polymorphism reveals extensive adaptation in Drosophila.Genetics · 2007Article
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Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A scan of the X chromosome of a European Drosophila melanogaster population revealed evidence for the recent action of positive directional selection at individual loci. In this study we analyze one such region that showed no polymorphism in the genome scan (located in cytological division 2C10-2E1). We detect a 60.5-kb stretch of DNA encompassing the genes ph-d, ph-p, CG3835, bcn92, Pgd, wapl, and Cyp4d1, which almost completely lacks variation in the European sample. Loci flanking this region show a skewed frequency spectrum at segregating sites, strong haplotype structure, and high levels of linkage disequilibrium. Neutrality tests reveal that these data are unlikely under both the neutral equilibrium model and the simple bottleneck scenarios. In contrast, newly developed maximum-likelihood ratio tests suggest that strong selection has acted recently on the region under investigation, causing a selective sweep. Evidence that this sweep may have originated in an ancestral population in Africa is presented.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.