ArticleGenome research2005
Evolutionary constraints in conserved nongenic sequences of mammals.
Article in Genome research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 57 citations in OpenAlex.
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- Convergent evolution of the genomes of marine mammals.Nature genetics · 2015Article
- Cis-regulatory elements and human evolution.Current opinion in genetics & development · 2014Review
- Abnormal dosage of ultraconserved elements is highly disfavored in healthy cells but not cancer cells.PLoS genetics · 2014Article
- The QTN program and the alleles that matter for evolution: all that's gold does not glitter.Evolution; international journal of organic evolution · 2012Article
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- Ranking insertion, deletion and nonsense mutations based on their effect on genetic information.BMC bioinformatics · 2011Article
- Evolution in health and medicine Sackler colloquium: Genetic architecture of a complex trait and its implications for fitness and genome-wide association studies.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- The genetics of inbreeding depression.Nature reviews. Genetics · 2009Review
- Evolutionary processes acting on candidate cis-regulatory regions in humans inferred from patterns of polymorphism and divergence.PLoS genetics · 2009Article
- Widespread genomic signatures of natural selection in hominid evolution.PLoS genetics · 2009Article
- Power of deep, all-exon resequencing for discovery of human trait genes.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Selection and mutation on microRNA target sequences during rice evolution.BMC genomics · 2008Article
- Fast evolution of core promoters in primate genomes.Molecular biology and evolution · 2008Article
- Life-history traits drive the evolutionary rates of mammalian coding and noncoding genomic elements.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Analysis of sequence conservation at nucleotide resolution.PLoS computational biology · 2007Article
- The other side of the nearly neutral theory, evidence of slightly advantageous back-mutations.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Adaptive evolution of conserved noncoding elements in mammals.PLoS genetics · 2007Article
- A model of evolution with constant selective pressure for regulatory DNA sites.BMC evolutionary biology · 2007Article
- Widely distributed noncoding purifying selection in the human genome.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammalian genomes contain many highly conserved nongenic sequences (CNGs) whose functional significance is poorly understood. Sets of CNGs have previously been identified by selecting the most conserved elements from a chromosome or genome, but in these highly selected samples, conservation may be unrelated to purifying selection. Furthermore, conservation of CNGs may be caused by mutation rate variation rather than selective constraints. To account for the effect of selective sampling, we have examined conservation of CNGs in taxa whose evolution is largely independent of the taxa from which the CNGs were initially identified, and we have controlled for mutation rate variation in the genome. We show that selective constraints in CNGs and their flanks are about one-half as strong in hominids as in murids, implying that hominids have accumulated many slightly deleterious mutations in functionally important nongenic regions. This is likely to be a consequence of the low effective population size of hominids leading to a reduced effectiveness of selection. We estimate that there are one and two times as many conserved nucleotides in CNGs as in known protein-coding genes of hominids and murids, respectively. Polymorphism frequencies in CNGs indicate that purifying selection operates in these sequences. During hominid evolution, we estimate that a total of about three deleterious mutations in CNGs and protein-coding genes have been selectively eliminated per diploid genome each generation, implying that deleterious mutations are eliminated from populations non-independently and that sex is necessary for long-term population persistence.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.