ArticleGenes & development2005
The Drosophila MSL complex activates the transcription of target genes.
Article in Genes & development, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed, 104 citations in OpenAlex.
- Transcription initiation drives dosage compensation establishment and maintenance in maleScience advances · 2026Article
- Nucleotide-Resolution Mapping Reveals Specific MLE Binding Site on roX2 lncRNA.Journal of molecular biology · 2026Article
- Parallel Evolution of X Chromosome-Specific Structural Maintenance of Chromosomes Complexes in Two Nematode Lineages.Molecular biology and evolution · 2025Article
- Novel protein-truncating variants of a chromatin-modifying gene MSL2 in syndromic neurodevelopmental disorders.European journal of human genetics : EJHG · 2024Article
- Loss of function of male-specific lethal 3 (Msl3) does not affect spermatogenesis in rodents.Developmental dynamics : an official publication of the American Association of Anatomists · 2024Article
- Cis- and trans-regulation by histone H4 basic patch R17/R19 in metazoan development.Open biology · 2022Article
- Masculinizer-induced dosage compensation is achieved by transcriptional downregulation of both copies of Z-linked genes in the silkworm,Biology letters · 2022Article
- Review
- Multilayered Tuning of Dosage Compensation and Z-Chromosome Masculinization in the Wood White (Leptidea sinapis) Butterfly.Genome biology and evolution · 2019Article
- Dosage-Dependent Expression Variation Suppressed on theG3 (Bethesda, Md.) · 2018Article
- RNA sequencing reveals a complete but an unconventional type of dosage compensation in the domestic silkwormRoyal Society open science · 2017Article
- Dosage compensation in Drosophila.Cold Spring Harbor perspectives in biology · 2015Review
- Article
- Modulation of Heterochromatin by Male Specific Lethal Proteins and roX RNA in Drosophila melanogaster Males.PloS one · 2015Article
- Review
- Revealing long noncoding RNA architecture and functions using domain-specific chromatin isolation by RNA purification.Nature biotechnology · 2014Article
- Complete dosage compensation and sex-biased gene expression in the moth Manduca sexta.Genome biology and evolution · 2014Article
- Transcriptional control of a whole chromosome: emerging models for dosage compensation.Nature structural & molecular biology · 2014Review
- The C. elegans dosage compensation complex mediates interphase X chromosome compaction.Epigenetics & chromatin · 2014Article
- Article
8 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanism through which gene expression originating from the single male or the two female X chromosomes in Drosophila is adjusted to autosomal gene expression has remained controversial. According to the prevalent model, transcription of the male X is increased twofold by the male-specific-lethal (MSL) complex. However, a significant body of data supports an alternative model, whereby compensation involves a global repression of autosomal gene expression in males by sequestration and neutralization of an activator onto the X chromosome. In order to rigorously discriminate between these models we identified direct target genes for the MSL complex and quantified transcription in absolute terms after knockdown of MSL2. The results unequivocally document an approximate twofold activation of target genes by the MSL complex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.