ArticleProceedings of the National Academy of Sciences of the United States of America2005
{gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 58 citations in OpenAlex.
- Azathioprine therapy selectively ablates human Vδ2⁺ T cells in Crohn's disease.The Journal of clinical investigation · 2015Trial
- Article
- Revisiting the past in light of current knowledge on γδ T cells in leishmaniasis.Frontiers in immunology · 2026Review
- Myo1f has an essential role in γδT intraepithelial lymphocyte adhesion and migration.Frontiers in immunology · 2023Article
- Indirect Impact of PD-1/PD-L1 Blockade on a Murine Model of NK Cell Exhaustion.Frontiers in immunology · 2020Article
- IL-7 is a Key Driver Cytokine in Spondyloarthritis?Journal of immunology research · 2019Review
- γδ T Cells Coexpressing Gut Homing α4β7 and αE Integrins Define a Novel Subset Promoting Intestinal Inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Interleukin-15 enhances the proliferation, stimulatory phenotype, and antitumor effector functions of human gamma delta T cells.Journal of hematology & oncology · 2016Article
- γδ T Cell-Dependent Regulatory T Cells Prevent the Development of Autoimmune Keratitis.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Dermal γδ T cells--What have we learned?Cellular immunology · 2015Review
- Homeostatic control of memory cell progenitors in the natural killer cell lineage.Cell reports · 2015Article
- Expanded Human Blood-Derived γδT Cells Display Potent Antigen-Presentation Functions.Frontiers in immunology · 2014Article
- γδ T cell and other immune cells crosstalk in cellular immunity.Journal of immunology research · 2014Review
- A canonical Vγ4Vδ4+ γδ T cell population with distinct stimulation requirements which promotes the Th17 response.Immunologic research · 2013Article
- Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing γδ cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- IL-7: the global builder of the innate lymphoid network and beyond, one niche at a time.Seminars in immunology · 2012Review
- Decreased interleukin 7 responsiveness of T lymphocytes in patients with idiopathic CD4 lymphopenia.The Journal of infectious diseases · 2012Article
- Homeostatic maintenance of T cells and natural killer cells.Cellular and molecular life sciences : CMLS · 2012Review
- CD4 T cells play important roles in maintaining IL-17-producing γδ T-cell subsets in naive animals.Immunology and cell biology · 2012Article
- Cutting edge: Generation of colitogenic Th17 CD4 T cells is enhanced by IL-17+ γδ T cells.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
gammadelta T cells are a diverse population of lymphocytes that play an important role in immune regulation. The size of the gammadelta T cell pool is tightly regulated, comprising only 1-10% of total lymphoid T cells in mice and humans. We examined the homeostatic regulation of gammadelta T cells using a model of lymphopenia-induced homeostatic expansion. We found that IL-15 and, to a lesser extent, IL-7 play an important role in lymphoid gammadelta T cell homeostasis. Moreover, gammadelta T cell homeostatic expansion was limited not only by gammadelta T cells themselves but also by natural killer cells and alphabeta T cells. Our results suggest that CD8(+) alphabeta T cells are the most potent inhibitors of gammadelta T cell homeostasis and exert their effect by competing for IL-15.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.