ArticleEnvironmental health perspectives2005
Fungal levels in the home and allergic rhinitis by 5 years of age.
Article in Environmental health perspectives, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- Association of indoor microbial aerosols with respiratory symptoms among under-five children: a systematic review and meta-analysis.Environmental health : a global access science source · 2021Pooled it
- Residential dampness and molds and the risk of developing asthma: a systematic review and meta-analysis.PloS one · 2012Pooled it
- Analysis of culturable airborne fungi in outdoor environments in Tianjin, China.BMC microbiology · 2021Article
- Comparison of the performance of ITS1 and ITS2 as barcodes in amplicon-based sequencing of bioaerosols.PeerJ · 2020Article
- Ten questions concerning the implications of carpet on indoor chemistry and microbiology.Building and environment · 2019Article
- International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis.International forum of allergy & rhinology · 2018Article
- Clinical relevance of IgE-mediated sensitization against the mould Alternaria alternata in children with asthma.Therapeutic advances in respiratory disease · 2017Article
- Characterisation of a flavonoid ligand of the fungal protein Alt a 1.Scientific reports · 2016Article
- Characterization of the bacterial and fungal microbiome in indoor dust and outdoor air samples: a pilot study.Environmental science. Processes & impacts · 2016Article
- Indoor environmental exposures and exacerbation of asthma: an update to the 2000 review by the Institute of Medicine.Environmental health perspectives · 2015Review
- Asthma and allergy development: contrasting influences of yeasts and other fungal exposures.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015Article
- Article
- Next-generation DNA sequencing reveals that low fungal diversity in house dust is associated with childhood asthma development.Indoor air · 2014Article
- Article
- Impact of fungal load on diagnosis and outcome of allergic fungal rhinosinusitis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2014Article
- Fungal pollution of indoor environments and its management.Saudi journal of biological sciences · 2012Article
- Infant origins of childhood asthma associated with specific molds.The Journal of allergy and clinical immunology · 2012Article
- Airborne fungi and bacteria in indoor and outdoor environment of the Pediatric Unit of Edirne Government Hospital.Environmental monitoring and assessment · 2012Article
- Home characteristics as predictors of bacterial and fungal microbial biomarkers in house dust.Environmental health perspectives · 2011Article
- Visually observed mold and moldy odor versus quantitatively measured microbial exposure in homes.The Science of the total environment · 2010Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
Studies have repeatedly demonstrated that sensitization to fungi, such as Alternaria, is strongly associated with allergic rhinitis and asthma in children. However, the role of exposure to fungi in the development of childhood allergic rhinitis is poorly understood. In a prospective birth cohort of 405 children of asthmatic/allergic parents from metropolitan Boston, Massachusetts, we examined in-home high fungal concentrations (> 90th percentile) measured once within the first 3 months of life as predictors of doctor-diagnosed allergic rhinitis in the first 5 years of life. In multivariate Cox regression analyses, predictors of allergic rhinitis included high levels of dust-borne Aspergillus [hazard ratio (HR) = 3.27; 95% confidence interval (CI), 1.50-7.14], Aureobasidium (HR = 3.04; 95% CI, 1.33-6.93), and yeasts (HR = 2.67; 95% CI, 1.26-5.66). The factors controlled for in these analyses included water damage or mild or mildew in the building during the first year of the child's life, any lower respiratory tract infection in the first year, male sex, African-American race, fall date of birth, and maternal IgE to Alternaria > 0.35 U/mL. Dust-borne Alternaria and nonsporulating and total fungi were also predictors of allergic rhinitis in models excluding other fungi but adjusting for all of the potential confounders listed above. High measured fungal concentrations and reports of water damage, mold, or mildew in homes may predispose children with a family history of asthma or allergy to the development of allergic rhinitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.