ArticleEnvironmental health perspectives2005
Increased levels of 8-hydroxy-2 -deoxyguanosine attributable to carcinogenic metal exposure among schoolchildren.
Article in Environmental health perspectives, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 88 citations in OpenAlex.
- Exposure to a mixture of four metals and associations with urinary oxidative stress biomarkers in Uruguayan adolescents.Journal of environmental exposure assessment · 2025Article
- Genotoxic Biomonitoring in Children Living near the El Fraile Mine Tailings in Northern Guerrero State, Mexico.Toxics · 2022Article
- Urinary 8-OHdG level is not affected by geography and trace elements in nail of residents of Addis Ababa: It is shaped by interactions between different social factors.Toxicology reports · 2022Article
- Use of toenail-bounded heavy metals to characterize occupational exposure and oxidative stress in workers of waterpipe/cigarette cafés.Environmental geochemistry and health · 2021Article
- Emission-related Heavy Metal Associated with Oxidative Stress in Children: Effect of Antioxidant Intake.International journal of environmental research and public health · 2020Article
- Suitability of MDA, 8-OHdG and wild-type p53 as genotoxic biomarkers in metal (Co, Ni and Cr) exposed dental technicians: a cross-sectional study.BMC oral health · 2020Article
- Urinary metabolites of polycyclic aromatic hydrocarbons in pregnant women and their association with a biomarker of oxidative stress.Environmental science and pollution research international · 2019Article
- Blood concentrations of lead, cadmium, mercury and their association with biomarkers of DNA oxidative damage in preschool children living in an e-waste recycling area.Environmental geochemistry and health · 2018Article
- A Comparison of the Health Effects of Ambient Particulate Matter Air Pollution from Five Emission Sources.International journal of environmental research and public health · 2018Review
- Oxidative stress and DNA repair and detoxification gene expression in adolescents exposed to heavy metals living in the Milazzo-Valle del Mela area (Sicily, Italy).Redox biology · 2014Article
- Can 8-hydroxy-2'-deoxyguanosine be used to assess oxidative stress caused by particulate matter air pollution in the general population?International journal of public health · 2013Article
- Malondialdehyde-deoxyguanosine and bulky DNA adducts in schoolchildren resident in the proximity of the Sarroch industrial estate on Sardinia Island, Italy.Mutagenesis · 2013Article
- Adverse health effects of child labor: high exposure to chromium and oxidative DNA damage in children manufacturing surgical instruments.Environmental health perspectives · 2012Article
- Genetic predisposition for dermal problems in hexavalent chromium exposed population.Journal of nucleic acids · 2012Article
- Biomarkers of oxidative stress and its association with the urinary reducing capacity in bus maintenance workers.Journal of occupational medicine and toxicology (London, England) · 2011Article
- Developmental neurotoxicants in e-waste: an emerging health concern.Environmental health perspectives · 2011Review
- 8-Hydroxy-2'-deoxyguanosine as a marker of oxidative DNA damage related to occupational and environmental exposures.International archives of occupational and environmental health · 2006Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arsenic, chromium, and nickel are reported in several epidemiologic studies to be associated with lung cancer. However, the health effects of arsenic, chromium, and nickel exposures are equivocal for children. Therefore, we performed a cross-sectional study to investigate possible associations between the internal concentrations of arsenic, chromium, and nickel and the level of oxidative stress to DNA in children. We measured urinary levels of arsenic, chromium, and nickel for 142 nonsmoking children using atomic absorption spectrometry. As a biomarker for oxidative stress, urinary 8-hydroxy-2 -deoxyguanosine (8-OHdG) levels were analyzed with an enzyme-linked immunosorbent assay kit. The median urinary 8-OHdG level for our subjects was 11.7 ng/mg creatinine. No obvious relationship between the levels of urinary nickel and 8-OHdG was found. Multiple linear regression analysis showed that children with higher urinary chromium had greater urinary 8-OHdG than did those with lower urinary chromium. Similarly, subjects with higher urinary arsenic had greater urinary 8-OHdG than did those with lower urinary arsenic. Furthermore, children with both high urinary arsenic and high urinary chromium had the highest 8-OHdG levels (mean +/- SE, 16.0 +/- 1.3; vs. low arsenic/low chromium, p < 0.01) in urine, followed by those with low arsenic/high chromium (13.7 +/- 1.6; vs. low arsenic/low chromium, p = 0.25), high arsenic/low chromium (12.9 +/- 1.6 vs. low arsenic/low chromium, p = 0.52), and low arsenic/low chromium (11.5 +/- 1.3); the trend was significant (p < 0.001). Thus, environmental carcinogenic metal exposure to chromium and arsenic may play an important role in oxidative DNA damage to children.
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