ReviewJournal of cellular and molecular medicine
Tissue engineering of cultured skin substitutes.
Review in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 296 citations in OpenAlex.
- Epidermal Keratinocyte Cells in Laboratory, Clinical Trials, and Market: A Narrative Review.Health science reports · 2025Review
- Tissue Regeneration of Radiation-Induced Skin Damages Using Protein/Polysaccharide-Based Bioengineered Scaffolds and Adipose-Derived Stem Cells: A Review.International journal of molecular sciences · 2025Review
- Cosmetic Outcomes of the First Bodybuilder Using a Low-Cost Modified Culture Technique for Burn Wound Coverage: A Case Report and Long-Term Follow-Up.European burn journal · 2025Article
- Cellulose-Based Nanofibers Infused with Biotherapeutics for Enhanced Wound-Healing Applications.ACS polymers Au · 2025Review
- Early Detection, Diagnosis, Prevention, and Treatment of Infection to Avoid Sepsis and Septic Shock in Severely Burned Patients: A Narrative Review.European burn journal · 2025Review
- Growth factors IGF-1 and KGF and adipose-derived stem cells promote migration and viability of primary human keratinocytes in anFrontiers in medicine · 2025Article
- Lyophilized Polyvinyl Alcohol and Chitosan Scaffolds Pre-Loaded with Silicon Dioxide Nanoparticles for Tissue Regeneration.Molecules (Basel, Switzerland) · 2024Article
- Bioinspired skin towards next-generation rehabilitation medicine.Frontiers in bioengineering and biotechnology · 2023Review
- Polymeric biomaterials for wound healing.Frontiers in bioengineering and biotechnology · 2023Review
- Air-Pressure-Supported Application of Cultured Human Keratinocytes in a Fibrin Sealant Suspension as a Potential Clinical Tool for Large-Scale Wounds.Journal of clinical medicine · 2022Article
- -Omics potential of in vitro skin models for radiation exposure.Cellular and molecular life sciences : CMLS · 2022Review
- Basic Quality Controls Used in Skin Tissue Engineering.Life (Basel, Switzerland) · 2021Review
- Mathematical Modeling Can Advance Wound Healing Research.Advances in wound care · 2021Review
- Translational stem cell therapy: vascularized skin grafts in skin repair and regeneration.Journal of translational medicine · 2021Review
- Recent Advances of Biomedical Materials for Prevention of Post-ESD Esophageal Stricture.Frontiers in bioengineering and biotechnology · 2021Review
- Keratinocyte Monolayers on Hyaluronic Acid Membranes as "Upside-Down" Grafts Reconstitute Full-Thickness Wounds.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Strategies to prevent stricture after esophageal endoscopic submucosal dissection.Annals of translational medicine · 2019Review
- Wound healing complications in oncological patients: perspectives for cellular therapy.Postepy dermatologii i alergologii · 2019Review
- Enhanced osteogenic commitment of murine mesenchymal stem cells on graphene oxide substrate.Biomaterials research · 2018Article
- Anisotropic dehydration of hydrogel surfaces.Progress in biomaterials · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skin replacement has been a challenging task for surgeons ever since the introduction of skin grafts by Reverdin in 1871. Recently, skin grafting has evolved from the initial autograft and allograft preparations to biosynthetic and tissue-engineered living skin replacements. This has been fostered by the dramatically improved survival rates of major burns where the availability of autologous normal skin for grafting has become one of the limiting factors. The ideal properties of a temporary and a permanent skin substitute have been well defined. Tissue-engineered skin replacements: cultured autologous keratinocyte grafts, cultured allogeneic keratinocyte grafts, autologous/allogeneic composites, acellular biological matrices, and cellular matrices including such biological substances as fibrin sealant and various types of collagen, hyaluronic acid etc. have opened new horizons to deal with such massive skin loss. In extensive burns it has been shown that skin substitution with cultured grafts can be a life-saving measure where few alternatives exist. Future research will aim to create skin substitutes with cultured epidermis that under appropriate circumstances may provide a wound cover that could be just as durable and esthetically acceptable as conventional split-thickness skin grafts. Genetic manipulation may in addition enhance the performance of such cultured skin substitutes. If cell science, molecular biology, genetic engineering, material science and clinical expertise join their efforts to develop optimized cell culture techniques and synthetic or biological matrices then further technical advances might well lead to the production of almost skin like new tissue-engineered human skin products resembling natural human skin.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.