ReviewJournal of cellular and molecular medicine
Progenitor cells in vascular disease.
Review in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 89 citations in OpenAlex.
- Downregulation of the Long Non-Coding RNALife (Basel, Switzerland) · 2026Article
- Challenges and opportunities in the islet transplantation microenvironment: a comprehensive summary of inflammatory cytokine, immune cells, and vascular endothelial cells.Frontiers in immunology · 2023Review
- Impaired LEF1 Activation Accelerates iPSC-Derived Keratinocytes Differentiation in Hutchinson-Gilford Progeria Syndrome.International journal of molecular sciences · 2022Article
- Article
- Mediterranean Diet and Endothelial Function: A Review of its Effects at Different Vascular Bed Levels.Nutrients · 2020Review
- Endothelial Progenitor Cells as a Marker of Vascular Damage But not a Predictor in Acute Microangiopathy-Associated Stroke.Journal of clinical medicine · 2020Article
- Tryptase promotes breast cancer angiogenesis through PAR-2 mediated endothelial progenitor cell activation.Oncology letters · 2018Article
- Mobilization of endothelial progenitor cell in patients with acute ischemic stroke.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Article
- Kinetics of circulating endothelial progenitor cells in patients undergoing carotid artery surgery.Therapeutics and clinical risk management · 2016Article
- Loss of endothelial-ARNT in adult mice contributes to dampened circulating proangiogenic cells and delayed wound healing.Vascular medicine (London, England) · 2014Article
- Microvascular repair: post-angiogenesis vascular dynamics.Microcirculation (New York, N.Y. : 1994) · 2012Review
- Monocyte chemoattractant protein-1/CCR2 axis promotes vein graft neointimal hyperplasia through its signaling in graft-extrinsic cell populations.Arteriosclerosis, thrombosis, and vascular biology · 2012Article
- Endothelial progenitor cells: current issues on characterization and challenging clinical applications.Stem cell reviews and reports · 2012Review
- In vitro labeling of endothelial progenitor cells isolated from peripheral blood with superparamagnetic iron oxide nanoparticles.Molecular medicine reports · 2012Article
- Calcitonin gene-related peptide released from endothelial progenitor cells inhibits the proliferation of rat vascular smooth muscle cells induced by angiotensin II.Molecular and cellular biochemistry · 2011Article
- Biological characteristics of foam cell formation in smooth muscle cells derived from bone marrow stem cells.International journal of biological sciences · 2011Article
- Osteocalcin positive mononuclear cells are associated with the severity of aortic calcification.Atherosclerosis · 2010Article
- Differentiation patterning of vascular smooth muscle cells (VSMC) in atherosclerosis.Virchows Archiv : an international journal of pathology · 2009Article
- Cell therapy of hip osteonecrosis with autologous bone marrow grafting.Indian journal of orthopaedics · 2009Article
- Thrombin bound to a fibrin clot confers angiogenic and haemostatic properties on endothelial progenitor cells.Journal of cellular and molecular medicine · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stem cell research has the potential to provide solutions to many chronic diseases via the field of regeneration therapy. In vascular biology, endothelial progenitor cells (EPCs) have been identified as contributing to angiogenesis and hence have therapeutic potential to revascularise ischaemic tissues. EPCs have also been shown to endothelialise vascular grafts and therefore may contribute to endothelial maintenance. EPC number has been shown to be reduced in patients with cardiovascular disease, leading to speculation that atherosclerosis may be caused by a consumptive loss of endothelial repair capacity. Animal experiments have shown that EPCs reendothelialise injured vessels and that this reduces neointimal formation, confirming that EPCs have an atheroprotective effect. Smooth muscle cell accumulation in the neointimal space is characteristic of many forms of atherosclerosis, however the source of these cells is now thought to be from smooth muscle progenitor cells (SMPCs) rather than the adjacent media. There is evidence for the presence of SMPCs in the adventitia of animals and that SMPCs circulate in human blood. There is also data to support SMPCs contributing to neointimal formation but their origin remains unknown. This article will review the roles of EPCs and SMPCs in the development of vascular disease by examining experimental data from in vitro studies, animal models of atherosclerosis and clinical studies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.