ReviewJournal of cellular and molecular medicine
The molecular basis of transdifferentiation.
Review in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- PPARγ Mediates Transdifferentiation of CX3CR1International journal of molecular sciences · 2026Article
- Expression profiling of stemness markers in testicular germline stem cells from neonatal and adult Swiss albino mice during their transdifferentiation in vitro.Stem cell research & therapy · 2024Article
- Article
- Effect of ciglitazone on adipogenic transdifferentiation of bovine skeletal muscle satellite cells.Journal of animal science and technology · 2021Article
- Identification of MyoD-Responsive Transcripts Reveals a Novel Long Non-coding RNA (lncRNA-AK143003) that Negatively Regulates Myoblast Differentiation.Scientific reports · 2017Article
- Retinoic acid maintains human skeletal muscle progenitor cells in an immature state.Cellular and molecular life sciences : CMLS · 2017Article
- Techniques of Human Embryonic Stem Cell and Induced Pluripotent Stem Cell Derivation.Archivum immunologiae et therapiae experimentalis · 2016Review
- Activation of PPARγ2 by PPARγ1 through a functional PPRE in transdifferentiation of myoblasts to adipocytes induced by EPA.Cell cycle (Georgetown, Tex.) · 2015Article
- Pancreatic and duodenal homeobox gene 1 (Pdx1) down-regulates hepatic transcription factor 1 alpha (HNF1α) expression during reprogramming of human hepatic cells into insulin-producing cells.American journal of translational research · 2015Article
- Lineage conversion methodologies meet the reprogramming toolbox.Nature cell biology · 2012Review
- A case of cellular alchemy: lineage reprogramming and its potential in regenerative medicine.Journal of molecular cell biology · 2012Review
- β-cell preservation and regeneration for diabetes treatment: where are we now?Diabetes management (London, England) · 2012Article
- Monocytes do not transdifferentiate into proper osteoblasts.TheScientificWorldJournal · 2012Article
- Dexamethasone treatment induces the reprogramming of pancreatic acinar cells to hepatocytes and ductal cells.PloS one · 2010Article
- Hepatocyte nuclear factor-4alpha induces transdifferentiation of hematopoietic cells into hepatocytes.The Journal of biological chemistry · 2010Article
- Regenerating pancreatic beta-cells: plasticity of adult pancreatic cells and the feasibility of in-vivo neogenesis.Current opinion in organ transplantation · 2010Review
- Exendin-4 promotes liver cell proliferation and enhances the PDX-1-induced liver to pancreas transdifferentiation process.The Journal of biological chemistry · 2009Article
- Insulin protein and proliferation in ductal cells in the transplanted pancreas of patients with type 1 diabetes and recurrence of autoimmunity.Diabetologia · 2008Article
- Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia.The American journal of pathology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
There is now excellent experimental evidence demonstrating the remarkable ability of some differentiated cells to convert to a completely different phenotype. The conversion of one cellular phenotype to another is referred to as 'transdifferentiation' and belongs to a wider class of cell-type switches termed 'metaplasias'. Defining the molecular steps in transdifferentiation will help us to understand the developmental biology of the cells that interconvert, as well as help identify key regulatory transcription factors that may be important for the reprogramming of stem cells. Ultimately, being able to produce cells at will offers a compelling new approach to therapeutic transplantation and therefore the treatment and cure of diseases such as diabetes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.