ReviewJournal of cellular and molecular medicine
The last neuronal division: a unifying hypothesis for the pathogenesis of Alzheimer's disease.
Review in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
- Cellular Senescence in Neurodegenerative Diseases.Frontiers in cellular neuroscience · 2020Review
- The Possibility of an Infectious Etiology of Alzheimer Disease.Molecular neurobiology · 2019Review
- Ageing, Cellular Senescence and Neurodegenerative Disease.International journal of molecular sciences · 2018Review
- Neuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathways.BMC neuroscience · 2015Review
- Article
- Dysfunction of the mTOR pathway is a risk factor for Alzheimer's disease.Acta neuropathologica communications · 2013Article
- Reciprocal induction between α-synuclein and β-amyloid in adult rat neurons.Neurotoxicity research · 2013Article
- Oxidative modification of lipoic acid by HNE in Alzheimer disease brain.Redox biology · 2013Article
- G1/S cell cycle checkpoint defect in lymphocytes from patients with Alzheimer's disease.Psychiatry investigation · 2012Article
- Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria.Journal of neuroinflammation · 2011Review
- Rosuvastatin and thapsigargin modulate γ-secretase gene expression and APP processing in a human neuroglioma model.Journal of molecular neuroscience : MN · 2011Article
- A conceptual framework for interdisciplinary curriculum design: a case study in neuroscience.Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2011Article
- Simvastatin overcomes the resistance to serum withdrawal-induced apoptosis of lymphocytes from Alzheimer's disease patients.Cellular and molecular life sciences : CMLS · 2010Article
- Activation of ataxia telangiectasia muted under experimental models and human Parkinson's disease.Cellular and molecular life sciences : CMLS · 2010Article
- Apolipoprotein E mediates sulfatide depletion in animal models of Alzheimer's disease.Neurobiology of aging · 2010Article
- PKR, the double stranded RNA-dependent protein kinase as a critical target in Alzheimer's disease.Journal of cellular and molecular medicine · 2009Review
- Pharmacotherapeutic targets in Alzheimer's disease.Journal of cellular and molecular medicine · 2009Review
- Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set.Physiological genomics · 2008Article
- Cell cycle molecules define a pathway required for neuron death in development and disease.Biochimica et biophysica acta · 2007Review
- Proteomics in neurodegeneration--disease driven approaches.Journal of neural transmission (Vienna, Austria : 1996) · 2006Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease is the third biggest killer in the developed world after cancer and heart disease. Although the first description dates back to almost a century ago, we still do not understand the cellular-molecular mechanisms that lead to the development of the brain pathology. There is no efficient treatment for the patients. And even the symptomatic relief comes too late, because there is no diagnostic method that could identify patients before severe clinical symptoms develop. Almost every aspect of Alzheimer's research, whether on pathogenesis, diagnosis, risk factors or treatment strategies, seem to spark controversy nowadays. Studies that apparently contradict one another or propose alternate explanations are published monthly. Patients' hopes are raised with the announcement of each new drug trial. Then hope is lost when the trials fail. Ironically, while progressive research is hampered by apparent contradictions and lack of funding, the old dogmas survive in the textbooks and no real progress is made in terms of therapy. The purpose of this review is to take stock of the most discussed and most strongly opposing views on the pathogenesis of Alzheimer's disease. These views shape the Alzheimer field currently and some will hopefully one day shape the diagnostic and therapeutic approaches to the disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.