ArticleMolecular and cellular biology1992
Nucleotide sequence and transcriptional regulation of the yeast recombinational repair gene RAD51.
Article in Molecular and cellular biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers.
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Who cites it
115 citing papers in PubMed, 243 citations in OpenAlex.
- The negligible mutagenic effects of norfloxacin on the genome of the fission yeastMicrobiology spectrum · 2025Article
- Proteasome-mediated degradation of long-range nucleases negatively regulates resection of DNA double-strand breaks.iScience · 2024Article
- Meiotic DNA breaks activate a streamlined phospho-signaling response that largely avoids protein-level changes.Life science alliance · 2022Article
- Cellular response to moderate chromatin architectural defects promotes longevity.Science advances · 2019Article
- Live cell monitoring of double strand breaks in S. cerevisiae.PLoS genetics · 2019Article
- Caffeine inhibits gene conversion by displacing Rad51 from ssDNA.Nucleic acids research · 2015Article
- A novel sigma factor reveals a unique regulon controlling cell-specific recombination in Mycoplasma genitalium.Nucleic acids research · 2015Article
- Review
- Both OsRecQ1 and OsRDR1 are required for the production of small RNA in response to DNA-damage in rice.PloS one · 2013Article
- Article
- Forward chemical genetics in yeast for discovery of chemical probes targeting metabolism.Molecules (Basel, Switzerland) · 2012Review
- The role of Holliday junction resolvases in the repair of spontaneous and induced DNA damage.Nucleic acids research · 2011Article
- Initiation and completion of spontaneous mitotic recombination occur in different cell cycle phases.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Role of the homologous recombination genes RAD51 and RAD59 in the resistance of Candida albicans to UV light, radiomimetic and anti-tumor compounds and oxidizing agents.Fungal genetics and biology : FG & B · 2010Article
- Plant DNA recombinases: a long way to go.Journal of nucleic acids · 2010Article
- Analysis of repair mechanism choice during homologous recombination.Nucleic acids research · 2009Article
- Suppression of the double-strand-break-repair defect of the Saccharomyces cerevisiae rad57 mutant.Genetics · 2009Article
- The rad51-K191R ATPase-defective mutant is impaired for presynaptic filament formation.Molecular and cellular biology · 2006Article
- Enhanced stimulation of chromosomal translocations and sister chromatid exchanges by either HO-induced double-strand breaks or ionizing radiation in Saccharomyces cerevisiae yku70 mutants.Mutation research · 2005Article
- Homologous recombination is involved in transcription-coupled repair of UV damage in Saccharomyces cerevisiae.The EMBO journal · 2005Article
55 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The RAD51 gene of Saccharomyces cerevisiae is required both for recombination and for the repair of DNA damage caused by X rays. Here we report the sequence and transcriptional regulation of this gene. The RAD51 protein shares significant homology (approximately 50%) over a 70-amino-acid with the RAD57 protein (J.A. Kans and R.K. Mortimer, Gene 105:139-140, 1991), the product of another yeast recombinational repair gene, and also moderate (approximately 27%), but potentially significant, homology with the bacterial RecA protein. The homologies cover a region that encodes a putative nucleotide binding site of the RAD51 protein. Sequences upstream of the coding region for RAD51 protein share homology with the damage response sequence element of RAD54, an upstream activating sequence required for damage regulation of the RAD54 transcript, and also contain two sites for restriction enzyme MluI; the presence of MluI restriction sites has been associated with cell cycle regulation. A 1.6-kb transcript corresponding to RAD51 was observed, and levels of this transcript increased rapidly after exposure to relatively low doses of X-rays. Additionally, RAD51 transcript levels were found to that of a group of genes involved primarily in DNA synthesis and replication which are thought to be coordinately cell cycle regulated. Cells arrested in early G1 were still capable of increasing levels of RAD51 transcript after irradiation, indicating that increased RAD51 transcript levels after X-ray exposure are not solely due to an X-ray-induced cessation of the cell cycle at a period when the level of RAD51 expression is normally high.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.