ArticleMolecular genetics and genomics : MGG2005
Sir-dependent downregulation of various aging processes.
Article in Molecular genetics and genomics : MGG, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Screening for long-lived genes identifies Oga1, a guanine-quadruplex associated protein that affects the chronological lifespan of the fission yeast Schizosaccharomyces pombe.Molecular genetics and genomics : MGG · 2013Article
- Evaluation of free-radical quenching properties of standard Ayurvedic formulation Vayasthapana Rasayana.BMC complementary and alternative medicine · 2011Article
- A fitness-based interferential genetics approach using hypertoxic/inactive gene alleles as references.Molecular genetics and genomics : MGG · 2009Article
- Function of Arabidopsis hexokinase-like1 as a negative regulator of plant growth.Journal of experimental botany · 2009Article
- Article
- A potentially general method for the in vivo selection of inhibitory peptides targeted at a specific protein using yeast.Current genetics · 2008Article
- Characterization of regulatory non-catalytic hexokinases in Aspergillus nidulans.Molecular genetics and genomics : MGG · 2007Article
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1 author at 1 institution in 1 country.
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Abstract
Using a new genetic selection approach in yeast termed fitness-based interferential genetics (FIG), genes that are in an antagonistic relationship with the Sir complexes were selected. Many of the functionally well-defined genes belong to various aging processes occurring in this organism. Three genes are somehow involved in glucose utilization (HXT4,YIL107c, EMI2). Another gene, CDC25, encodes the main regulator of the cyclic AMP pathway in response to glucose. STM1 has been implicated in the control of apoptosis, and indeed, this work shows that disruption of this gene results, among other phenotypes, in resistance to aging. LCB4, encoding a sphingoid bases kinase is linked to the cell integrity pathway. Two other genes, FHL1 and PEP5, are involved in the control of ribosome formation and vacuole biogenesis, respectively; and five genes, presently having unknown functions, could be new potentially interesting candidates for further studies in relation to yeast replicative aging. It is proposed that most, if not all, selected genes are downregulated by the Sir complexes. In addition to changing our view of the mechanisms used by the Sir complexes for extending life span in yeast, these findings could contribute to a better understanding of the role of the Sir complexes in the higher eukaryotes.
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