ArticlePlanta2006
Expression of the ubiquitin variant ubR48 decreases proteolytic activity in Arabidopsis and induces cell death.
Article in Planta, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Phototropin2 LOV1 plays a role in strong light signal transduction leading to chloroplast avoidance response.Acta physiologiae plantarum · 2026Article
- Transcriptome, metabolome and suppressor analysis reveal an essential role for the ubiquitin-proteasome system in seedling chloroplast development.BMC plant biology · 2022Article
- Integration of Small RNA and Degradome Sequencing Reveals the Regulatory Network of Al-Induced Programmed Cell Death in Peanut.International journal of molecular sciences · 2021Article
- The Blue Light-Dependent Polyubiquitination and Degradation of Arabidopsis Cryptochrome2 Requires Multiple E3 Ubiquitin Ligases.Plant & cell physiology · 2016Article
- Protein abundance changes and ubiquitylation targets identified after inhibition of the proteasome with syringolin A.Molecular & cellular proteomics : MCP · 2014Article
- Conditional involvement of constitutive photomorphogenic1 in the degradation of phytochrome A.Plant physiology · 2013Article
- Ubiquitination during plant immune signaling.Plant physiology · 2012Review
- Tandem affinity purification and mass spectrometric analysis of ubiquitylated proteins in Arabidopsis.The Plant journal : for cell and molecular biology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ubiquitin-proteasome pathway is the major route for protein degradation in eukaryotes. We show here that this pathway can be inhibited in Arabidopsis thaliana by expression of a ubiquitin variant that contains Arg instead of Lys at position 48 (ubR48). A major consequence of ubR48 expression is the induction of cell death. Cell death induction coincides with the appearance of reactive oxygen intermediates, but is independent of salicylic acid. We found changes in expression of some defense-related genes, but these changes are apparently insufficient to cause alterations in the response to a bacterial pathogen. Expression of ubR48 from an inducible gene allowed investigation of kinetic parameters of cell death induction. In the absence of additional stress factors, slow death processes dominate if the transgene is induced in seedlings older than 2 weeks. The inducible gene also allowed isolation of suppressor mutants. Expression of ubR48 may cause changes similar to inhibition of the proteasome, which also induces various forms of cell death. Thus, ubR48 is a tool to manipulate protein turnover and to probe cell death programs in plants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.