ReviewThe Journal of clinical investigation2005
Kidney stone disease.
Review in The Journal of clinical investigation, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03354507 (Use of Sodium Bicarbonate to Alkalinize Serum/Urine in Pediatric Patients Treated With Topiramate), which is not on this map. Cited by 275 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of Sodium Bicarbonate to Alkalinize Serum/Urine in Pediatric Patients Treated With Topiramate (Pilot Study)
Who cites it
275 citing papers in PubMed, 4 syntheses or guidelines pooled it, 769 citations in OpenAlex.
- Recent Progression and Treatment Approaches for the Kidney Stone Management.Current drug targets · 2025Pooled it
- Metabolic syndrome and nephrolithiasis: a systematic review and meta-analysis of the scientific evidence.Journal of nephrology · 2014Pooled it
- Metabolic disturbances and renal stone promotion on treatment with topiramate: a systematic review.British journal of clinical pharmacology · 2014Pooled it
- Effects of vitamin D receptor polymorphisms on urolithiasis risk: a meta-analysis.BMC medical genetics · 2013Pooled it
- Quantitative Susceptibility Mapping of Kidney Stones: An Ex Vivo MRI Phantom Study.Magnetic resonance in medicine · 2026Article
- Contributions of the anion exchangers SLC26A1, SLC26A2, SLC26A3, and SLC26A6 to intestinal oxalate transport in human Caco2-BBE cells.Physiological reports · 2026Article
- Animal Models of Hyperoxaluria and Their Relevance for Fundamental Research and Clinical Practice.International journal of molecular sciences · 2026Review
- Predictive value of family history of kidney stones for metabolic abnormalities and stone composition.World journal of urology · 2026Article
- Urolithiasis in patients with cancer.Nature reviews. Urology · 2026Review
- Composition and Biochemical Determinants of Renal Stones: A Comprehensive Analysis of Urinary and Serum Mineral Profiles.Urology research & practice · 2026Article
- Associations between dietary macronutrient composition and kidney stone prevalence in the U.S. adult population.Urolithiasis · 2026Article
- Article
- Predicting probiotic success: lessons from Oxalobacter and oxalate metabolism.NPJ biofilms and microbiomes · 2026Review
- When Stones Begin: Age of Onset Reveals the Systemic Metabolic Nature of Nephrolithiasis.Research and reports in urology · 2026Article
- CaSR regulates SLC26A6 expression via the PKA-FOXO4 signaling axis to promote experimental calcium oxalate kidney stone formation in rats.Frontiers in cell and developmental biology · 2026Article
- Serum calcium-magnesium-phosphate-potassium metabolic dysregulation in nephrolithiasis: predictive model development and mechanistic insights.Frontiers in physiology · 2026Article
- Inflammation-induced osteogenic signaling promotes calcium phosphate crystal formation in kidneys via MAPK, NF-κB, and smad pathways.Frontiers in cell and developmental biology · 2026Article
- Diversity in Clinical Characteristics and Composition of Urinary Stones in Different Regions of India and Comparison to Rest of the World.Annals of African medicine · 2026Review
- Metabolic abnormalities and recurrence in high-risk urinary stone formers: A prospective cohort study.Central European journal of urology · 2026Article
- Claudin-2 deficiency reveals a corticomedullary calcium gradient driving kidney stone formation.The Journal of clinical investigation · 2025Article
215 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
About 5% of American women and 12% of men will develop a kidney stone at some time in their life, and prevalence has been rising in both sexes. Approximately 80% of stones are composed of calcium oxalate (CaOx) and calcium phosphate (CaP); 10% of struvite (magnesium ammonium phosphate produced during infection with bacteria that possess the enzyme urease), 9% of uric acid (UA); and the remaining 1% are composed of cystine or ammonium acid urate or are diagnosed as drug-related stones. Stones ultimately arise because of an unwanted phase change of these substances from liquid to solid state. Here we focus on the mechanisms of pathogenesis involved in CaOx, CaP, UA, and cystine stone formation, including recent developments in our understanding of related changes in human kidney tissue and of underlying genetic causes, in addition to current therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.