ArticleEMBO reports2005
Helicase89B is a Mot1p/BTAF1 homologue that mediates an antimicrobial response in Drosophila.
Article in EMBO reports, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Control of lifespan and survival byAging · 2020Article
- Innate immune signaling in Drosophila shifts anabolic lipid metabolism from triglyceride storage to phospholipid synthesis to support immune function.PLoS genetics · 2020Article
- Alcohol resistance in Drosophila is modulated by the Toll innate immune pathway.Genes, brain, and behavior · 2016Article
- Ebi, a Drosophila homologue of TBL1, regulates the balance between cellular defense responses and neuronal survival.American journal of neurodegenerative disease · 2016Article
- Drosophila domino Exhibits Genetic Interactions with a Wide Spectrum of Chromatin Protein-Encoding Loci.PloS one · 2015Article
- Cellular Defense and Sensory Cell Survival Require Distinct Functions of ebi in Drosophila.PloS one · 2015Article
- Differential gene expression and alternative splicing in insect immune specificity.BMC genomics · 2014Article
- Broad RNA interference-mediated antiviral immunity and virus-specific inducible responses in Drosophila.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Genome-wide patterns of latitudinal differentiation among populations of Drosophila melanogaster from North America.Molecular ecology · 2012Article
- Characterization of the core elements of the NF-κB signaling pathway of the sea anemone Nematostella vectensis.Molecular and cellular biology · 2011Article
- NF-κB/Rel proteins and the humoral immune responses of Drosophila melanogaster.Current topics in microbiology and immunology · 2011Review
- Heterodimers of NF-kappaB transcription factors DIF and Relish regulate antimicrobial peptide genes in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Identification of Drosophila mutants altering defense of and endurance to Listeria monocytogenes infection.Genetics · 2008Article
- Dorsal interacting protein 3 potentiates activation by Drosophila Rel homology domain proteins.Developmental and comparative immunology · 2008Article
- Nuclear factor-kappa B pathways in Drosophila.Oncogene · 2006Review
- ATP-dependent chromatin remodeling complexes in Drosophila.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2006Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We have identified a novel component, Helicase89B, that is required for the inducible antimicrobial response in Drosophila larvae by means of a P-element insertional genetic screen. Helicase89B belongs to the Mot1p/BTAF1 subfamily of SNF2-like ATPases. This subfamily can interact with TATA-binding proteins, but whether the interaction leads to gene activation or repression is being debated. We found that Helicase89B is required for the inducible expression of antimicrobial peptide genes but not for the inducible expression of heat-shock genes. The antimicrobial peptide genes are activated by the Toll and immune deficiency (IMD) signalling pathways. Genetic experiments show that Helicase89B acts downstream of DIF and Relish, the two nuclear factor-kappaB (NF-kappaB)-related transcription factors that mediate Toll- and IMD-stimulated antimicrobial response. Thus, Helicase89B positively regulates gene expression during innate immune response and may act as a link between NF-kappaB-related transcription factors and the basal transcription machinery.
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