ArticleEndocrine pathology2005
BRAF copy number gains in thyroid tumors detected by fluorescence in situ hybridization.
Article in Endocrine pathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Immunophenotypic Panel for Comprehensive Characterization of Aggressive Thyroid Carcinomas.Cells · 2025Article
- Article
- Expression ofInternational journal of molecular sciences · 2024Article
- Relationship between TSHR, BRAF and PIK3CA gene copy number variations and thyroid nodules.Endocrine · 2021Article
- Characterization of TERT and BRAF copy number variation in papillary thyroid carcinoma: An analysis of the cancer genome atlas study.Genes, chromosomes & cancer · 2021Article
- Article
- Integrated Genomic Analysis of Hürthle Cell Cancer Reveals Oncogenic Drivers, Recurrent Mitochondrial Mutations, and Unique Chromosomal Landscapes.Cancer cell · 2018Article
- IncreasedOncology letters · 2015Article
- Genomic dissection of Hurthle cell carcinoma reveals a unique class of thyroid malignancy.The Journal of clinical endocrinology and metabolism · 2013Article
- Genomic differences in benign and malignant follicular thyroid tumours using 1-Mb array-comparative genomic hybridisation.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2013Article
- BRAF, GNAQ, and GNA11 mutations and copy number in pediatric low-grade glioma.FEBS open bio · 2012Article
- Utility of BRAF protein overexpression in predicting the metastasis potential of papillary thyroid carcinoma.Oncology letters · 2011Article
- DNA breaks at fragile sites generate oncogenic RET/PTC rearrangements in human thyroid cells.Oncogene · 2010Article
- Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo.Journal of hepatology · 2009Article
- Follicular histotypes of oncocytic thyroid carcinomas do not carry mutations of the BRAF hot-spot.World journal of surgery · 2008Article
- BRAF(E600) in benign and malignant human tumours.Oncogene · 2008Review
- Application of a BRAF pyrosequencing assay for mutation detection and copy number analysis in malignant melanoma.The Journal of molecular diagnostics : JMD · 2007Article
- Molecular pathology of adrenal cortical tumors: separating adenomas from carcinomas.Endocrine pathology · 2006Review
- Alterations of the BRAF gene in thyroid tumors.Endocrine pathology · 2005Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Point mutation of the BRAF gene is a common genetic event in papillary thyroid carcinomas. More recently, it has been found that BRAF can also participate in chromosomal rearrangement. In this study, we explore yet another possible mechanism of BRAF alteration, which involves copy number gain. Using fluorescence in situ hybridization with BRAF specific and chromosome 7 centromeric probes, we studied 62 follicular thyroid tumors and 32 papillary carcinomas. We found that numerical changes in BRAF copy number were rare in papillary thyroid carcinomas, while they occurred in 16-45% of follicular tumors of conventional and oncocytic (Hürthle cell) types. They were due to amplification of the gene or gain of one or more copies of chromosome 7. Tetrasomy for chromosome 7 was overall the most common finding. The changes in BRAF copy number did not overlap with RAS mutations in follicular tumors. In a group of follicular carcinomas, tumors with BRAF copy number gain were significantly more often widely invasive (67%) compared to tumors with no copy number change (18%). By Western blotting, the tumors carrying four copies of the gene revealed higher expression of BRAF protein, suggesting that copy number gain may represent another mechanism of BRAF activation in thyroid tumors.
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