ArticleMolecular and cellular biology2005
Global regulation by the yeast Spt10 protein is mediated through chromatin structure and the histone upstream activating sequence elements.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 65 citations in OpenAlex.
- Gene loss and cis-regulatory novelty shaped core histone gene evolution in the apiculate yeast Hanseniaspora uvarum.Genetics · 2024Article
- An epigenetically inherited UV hyper-resistance phenotype in Saccharomyces cerevisiae.Epigenetics & chromatin · 2022Article
- Physiological and Molecular Characterization of an Oxidative Stress-ResistantFrontiers in microbiology · 2022Article
- The Spt10 GNAT Superfamily Protein Modulates Development, Cell Cycle Progression and Virulence in the Fungal Insect Pathogen,Journal of fungi (Basel, Switzerland) · 2021Article
- The yeast ISW1b ATP-dependent chromatin remodeler is critical for nucleosome spacing and dinucleosome resolution.Scientific reports · 2021Article
- Statistical mechanics of chromosomes: in vivo and in silico approaches reveal high-level organization and structure arise exclusively through mechanical feedback between loop extruders and chromatin substrate properties.Nucleic acids research · 2020Article
- Self-Redirection of Metabolic Flux Toward Squalene and Ethanol Pathways by Engineered Yeast.Metabolites · 2020Article
- Boolean gene regulatory network model of centromere function in Saccharomyces cerevisiae.Journal of biological physics · 2019Article
- HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding.Molecular cell · 2019Article
- Bidirectional histone-gene promoters inFungal biology and biotechnology · 2019Article
- Association of improved oxidative stress tolerance and alleviation of glucose repression with superior xylose-utilization capability by a natural isolate ofBiotechnology for biofuels · 2018Article
- Regulation of DNA replication-coupled histone gene expression.Oncotarget · 2017Review
- Reduced Histone Expression or a Defect in Chromatin Assembly Induces Respiration.Molecular and cellular biology · 2016Article
- Cell cycle-regulated oscillator coordinates core histone gene transcription through histone acetylation.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Histone hypoacetylation-activated genes are repressed by acetyl-CoA- and chromatin-mediated mechanism.Biochimica et biophysica acta · 2014Article
- A compendium of nucleosome and transcript profiles reveals determinants of chromatin architecture and transcription.PLoS genetics · 2013Article
- Cell-cycle perturbations suppress the slow-growth defect of spt10Δ mutants in Saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2013Article
- m:Explorer: multinomial regression models reveal positive and negative regulators of longevity in yeast quiescence.Genome biology · 2012Article
- Regulation of histone gene expression in budding yeast.Genetics · 2012Review
- The replication-independent histone H3-H4 chaperones HIR, ASF1, and RTT106 co-operate to maintain promoter fidelity.The Journal of biological chemistry · 2012Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
The yeast SPT10 gene encodes a putative histone acetyltransferase (HAT) implicated as a global transcription regulator acting through basal promoters. Here we address the mechanism of this global regulation. Although microarray analysis confirmed that Spt10p is a global regulator, Spt10p was not detected at any of the most strongly affected genes in vivo. In contrast, the presence of Spt10p at the core histone gene promoters in vivo was confirmed. Since Spt10p activates the core histone genes, a shortage of histones could occur in spt10Delta cells, resulting in defective chromatin structure and a consequent activation of basal promoters. Consistent with this hypothesis, the spt10Delta phenotype can be rescued by extra copies of the histone genes and chromatin is poorly assembled in spt10Delta cells, as shown by irregular nucleosome spacing and reduced negative supercoiling of the endogenous 2mum plasmid. Furthermore, Spt10p binds specifically and highly cooperatively to pairs of upstream activating sequence elements in the core histone promoters [consensus sequence, (G/A)TTCCN(6)TTCNC], consistent with a direct role in histone gene regulation. No other high-affinity sites are predicted in the yeast genome. Thus, Spt10p is a sequence-specific activator of the histone genes, possessing a DNA-binding domain fused to a likely HAT domain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.