ArticleMolecular and cellular biology2005
Regulation of telomere length by an N-terminal region of the yeast telomerase reverse transcriptase.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Structural, functional, and stability change predictions in human telomerase upon specific point mutations.Scientific reports · 2019Article
- Yeast require redox switching in DNA primase.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Article
- A translocation-defective telomerase with low levels of activity and processivity stabilizes short telomeres and confers immortalization.Molecular biology of the cell · 2013Article
- A mutation in the catalytic subunit of yeast telomerase alters primer-template alignment while promoting processivity and protein-DNA binding.Journal of cell science · 2011Article
- Segregating YKU80 and TLC1 alleles underlying natural variation in telomere properties in wild yeast.PLoS genetics · 2009Article
- Inhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13p.Nucleic acids research · 2009Article
- Yeast Est2p affects telomere length by influencing association of Rap1p with telomeric chromatin.Molecular and cellular biology · 2008Article
- Characterization of physical and functional anchor site interactions in human telomerase.Molecular and cellular biology · 2007Article
- Modeling and structure function analysis of the putative anchor site of yeast telomerase.Nucleic acids research · 2007Article
- Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain.Molecular and cellular biology · 2006Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Telomerase is a reverse transcriptase that maintains chromosome integrity through synthesis of repetitive telomeric sequences on the ends of eukaryotic chromosomes. In the yeast Saccharomyces cerevisiae, telomere length homeostasis is achieved through negative regulation of telomerase access to the chromosome terminus by telomere-bound Rap1 protein and its binding partners, Rif1p and Rif2p, and positive regulation by factors such as Ku70/80, Tel1p, and Cdc13p. Here we report the identification of mutations within an N-terminal region (region I) of the yeast telomerase catalytic subunit (Est2p) that cause telomere lengthening without altering measurable catalytic properties of the enzyme in vitro. These telomerase mutations affect telomere length through a Ku-independent mechanism and do not alter chromosome end structure. While Tel1p is required for expression of the telomere-lengthening phenotype, Rif1p and Rif2p are not, suggesting that telomere overextension is independent of Rap1p. Taken together, these data suggest that specific amino acids within region I of the catalytic subunit of yeast telomerase play a previously unanticipated role in the response to Tel1p regulation at the telomere.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.