ArticleMolecular and cellular biology2005
Natural meiotic recombination hot spots in the Schizosaccharomyces pombe genome successfully predicted from the simple sequence motif M26.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 51 citations in OpenAlex.
- Creating Meiotic Recombination-Regulating DNA Sites byBiomolecules · 2024Article
- Metabolic stress-induced long ncRNA transcription governs the formation of meiotic DNA breaks in the fission yeast fbp1 gene.PloS one · 2024Article
- Article
- Molecular mechanisms for environmentally induced and evolutionarily rapid redistribution (plasticity) of meiotic recombination.Genetics · 2022Article
- Whole genome genetic variation and linkage disequilibrium in a diverse collection of Listeria monocytogenes isolates.PloS one · 2021Article
- Diverse DNA Sequence Motifs Activate Meiotic Recombination Hotspots Through a Common Chromatin Remodeling Pathway.Genetics · 2019Article
- Chromatin-mediated regulators of meiotic recombination revealed by proteomics of a recombination hotspot.Epigenetics & chromatin · 2018Article
- Sequence requirement of the ade6-4095 meiotic recombination hotspot in Schizosaccharomyces pombe.Genetica · 2018Article
- Correlation of Meiotic DSB Formation and Transcription Initiation Around Fission Yeast Recombination Hotspots.Genetics · 2017Article
- Functional organization of protein determinants of meiotic DNA break hotspots.Scientific reports · 2017Article
- Article
- Inferring outcrossing in the homothallic fungus Sclerotinia sclerotiorum using linkage disequilibrium decay.Heredity · 2014Article
- Recombination in the human Pseudoautosomal region PAR1.PLoS genetics · 2014Article
- High-resolution linkage map for two honeybee chromosomes: the hotspot quest.Molecular genetics and genomics : MGG · 2014Article
- DNA intermediates of meiotic recombination in synchronous S. pombe at optimal temperature.Nucleic acids research · 2014Article
- Acetylated Histone H3K9 is associated with meiotic recombination hotspots, and plays a role in recombination redundantly with other factors including the H3K4 methylase Set1 in fission yeast.Nucleic acids research · 2013Article
- Protein determinants of meiotic DNA break hot spots.Molecular cell · 2013Article
- New paradigms for conserved, multifactorial, cis-acting regulation of meiotic recombination.Nucleic acids research · 2012Review
- Nucleosomal organization of replication origins and meiotic recombination hotspots in fission yeast.The EMBO journal · 2012Article
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2 authors at 1 institution in 2 countries.
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Abstract
The M26 hot spot of meiotic recombination in Schizosaccharomyces pombe is the eukaryotic hot spot most thoroughly investigated at the nucleotide level. The minimum sequence required for M26 activity was previously determined to be 5'-ATGACGT-3'. Originally identified by a mutant allele, ade6-M26, the M26 heptamer sequence occurs in the wild-type S. pombe genome approximately 300 times, but it has been unclear whether any of these are active hot spots. Recently, we showed that the M26 heptamer forms part of a larger consensus sequence, which is significantly more active than the heptamer alone. We used this expanded sequence as a guide to identify a smaller number of sites most likely to be active hot spots. Ten of the 15 sites tested showed meiotic DNA breaks, a hallmark of recombination hot spots, within 1 kb of the M26 sequence. Among those 10 sites, one occurred within a gene, cds1(+), and hot spot activity of this site was confirmed genetically. These results are, to our knowledge, the first demonstration in any organism of a simple, defined nucleotide sequence accurately predicting the locations of natural meiotic recombination hot spots. M26 may be the first example among a diverse group of simple sequences that determine the distribution, and hence predictability, of meiotic recombination hot spots in eukaryotic genomes.
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