ArticleMolecular and cellular biology2005
The Xenopus ELAV protein ElrB represses Vg1 mRNA translation during oogenesis.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Article
- ELAVL1 and ELAVL4 are required for Musashi-dependent translational activation.bioRxiv : the preprint server for biology · 2026Article
- RNA binding proteins are potential novel biomarkers of egg quality in yellow catfish.BMC genomics · 2023Article
- T-Cell Intracellular Antigen 1-Like Protein in Physiology and Pathology.International journal of molecular sciences · 2022Review
- L-bodies are RNA-protein condensates driving RNA localization inMolecular biology of the cell · 2021Article
- Organizing the oocyte: RNA localization meets phase separation.Current topics in developmental biology · 2020Article
- Translational activation of maternally derived mRNAs in oocytes and early embryos and the role of embryonic poly(A) binding protein (EPAB).Biology of reproduction · 2019Review
- Ciphers and Executioners: How 3'-Untranslated Regions Determine the Fate of Messenger RNAs.Frontiers in genetics · 2019Review
- Increased Expression of Maturation Promoting Factor Components Speeds Up Meiosis in Oocytes from Aged Females.International journal of molecular sciences · 2018Article
- Fluorescence In Situ Hybridization of CryosectionedCold Spring Harbor protocols · 2018Article
- Controlling the Messenger: Regulated Translation of Maternal mRNAs in Xenopus laevis Development.Advances in experimental medicine and biology · 2017Review
- An oocyte-specific ELAVL2 isoform is a translational repressor ablated from meiotically competent antral oocytes.Cell cycle (Georgetown, Tex.) · 2014Article
- A perspective on photoperiodic phloem-mobile signals that control development.Frontiers in plant science · 2013Article
- The mRNA of a Knotted1-like transcription factor of potato is phloem mobile.Plant molecular biology · 2012Article
- Spatial regulation of translation through RNA localization.F1000 biology reports · 2012Article
- New insights into the regulation of RNP granule assembly in oocytes.International review of cell and molecular biology · 2012Review
- Xenopus germline nanos1 is translationally repressed by a novel structure-based mechanism.Development (Cambridge, England) · 2011Article
- Preparation of a highly active cell-free translation system from immature Xenopus laevis oocytes.Methods (San Diego, Calif.) · 2010Article
- Untranslated regions of a mobile transcript mediate RNA metabolism.Plant physiology · 2009Article
- Participation of Xenopus Elr-type proteins in vegetal mRNA localization during oogenesis.The Journal of biological chemistry · 2009Article
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3 authors at 1 institution in 1 country.
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Abstract
Xenopus laevis Vg1 mRNA undergoes both localization and translational control during oogenesis. We previously characterized a 250-nucleotide AU-rich element, the Vg1 translation element (VTE), in the 3'-untranslated region (UTR) of this mRNA that is responsible for the translational repression. UV-cross-linking and immunoprecipitation experiments, described here, revealed that the known AU-rich element binding proteins, ElrA and ElrB, and TIA-1 and TIAR interact with the VTE. The levels of these proteins during oogenesis are most consistent with a possible role for ElrB in the translational control of Vg1 mRNA, and ElrB, in contrast to TIA-1 and TIAR, is present in large RNP complexes. Immunodepletion of TIA-1 and TIAR from Xenopus translation extract confirmed that these proteins are not involved in the translational repression. Mutagenesis of a potential ElrB binding site destroyed the ability of the VTE to bind ElrB and also abolished translational repression. Moreover, multiple copies of the consensus motif both bind ElrB and support translational control. Therefore, there is a direct correlation between ElrB binding and translational repression by the Vg1 3'-UTR. In agreement with the reporter data, injection of a monoclonal antibody against ElrB into Xenopus oocytes resulted in the production of Vg1 protein, arguing for a role for the ELAV proteins in the translational repression of Vg1 mRNA during early oogenesis.
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