ArticleThe Plant cell2005
Mutation of the TGD1 chloroplast envelope protein affects phosphatidate metabolism in Arabidopsis.
Article in The Plant cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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Who cites it
79 citing papers in PubMed, 216 citations in OpenAlex.
- Disruption of starch biosynthesis and triacylglycerol degradation impairs growth but improves photosynthesis in Arabidopsis.The New phytologist · 2026Article
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- Inducible expression of DEFECTIVE IN ANTHER DEHISCENCE 1 enhances triacylglycerol accumulation and lipid droplet formation in vegetative tissues.The Plant journal : for cell and molecular biology · 2025Article
- Plasticity of the Arabidopsis leaf lipidome and proteome in response to pathogen infection and heat stress.Plant physiology · 2025Article
- Exploiting lipid droplet metabolic pathway to foster lipid production: oleosin in focus.Plant cell reports · 2024Review
- Plastid Transient and Stable Interactions with Other Cell Compartments.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Glycerol-3-Phosphate Acyltransferase GPAT9 Enhanced Seed Oil Accumulation and Eukaryotic Galactolipid Synthesis inInternational journal of molecular sciences · 2023Article
- Protein interactomes for plant lipid biosynthesis and their biotechnological applications.Plant biotechnology journal · 2023Review
- Bioengineering to Accelerate Biodiesel Production for a Sustainable Biorefinery.Bioengineering (Basel, Switzerland) · 2022Review
- Fatty acid desaturases (FADs) modulate multiple lipid metabolism pathways to improve plant resistance.Molecular biology reports · 2022Review
- Metabolic engineering of energycane to hyperaccumulate lipids in vegetative biomass.BMC biotechnology · 2022Article
- Proteins associated with the Arabidopsis thaliana plastid rhomboid-like protein RBL10.The Plant journal : for cell and molecular biology · 2021Article
- Trigalactosyldiacylglycerol 3 protein orthologs are required for basal disease resistance inPlant biotechnology (Tokyo, Japan) · 2021Article
- Allele mining in diverse accessions of tropical grasses to improve forage quality and reduce environmental impact.Annals of botany · 2021Article
- Alterations in the leaf lipidome of Brassica carinata under high-temperature stress.BMC plant biology · 2021Article
- Plastid Anionic Lipids Are Essential for the Development of Both Photosynthetic and Non-Photosynthetic Organs inInternational journal of molecular sciences · 2021Article
- Review
- Ectopic Expression ofPlants (Basel, Switzerland) · 2021Article
- Chloroplast lipid biosynthesis is fine-tuned to thylakoid membrane remodeling during light acclimation.Plant physiology · 2021Article
- Plastid Glycerol-3-phosphate Acyltransferase Enhanced Plant Growth and Prokaryotic Glycerolipid Synthesis inInternational journal of molecular sciences · 2020Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phosphatidate (PA) is a central metabolite of lipid metabolism and a signaling molecule in many eukaryotes, including plants. Mutations in a permease-like protein, TRIGALACTOSYLDIACYLGLYCEROL1 (TGD1), in Arabidopsis thaliana caused the accumulation of triacylglycerols, oligogalactolipids, and PA. Chloroplast lipids were altered in their fatty acid composition consistent with an impairment of lipid trafficking from the endoplasmic reticulum (ER) to the chloroplast and a disruption of thylakoid lipid biosynthesis from ER-derived precursors. The process mediated by TGD1 appears to be essential as mutation of the protein caused a high incidence of embryo abortion. Isolated tgd1 mutant chloroplasts showed a decreased ability to incorporate PA into galactolipids. The TGD1 protein was localized to the inner chloroplast envelope and appears to be a component of a lipid transporter. As even partial disruption of TGD1 function has drastic consequences on central lipid metabolism, the tgd1 mutant provides a tool to explore regulatory mechanisms governing lipid homeostasis and lipid trafficking in plants.
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