ArticleJournal of bacteriology2005
Rejection of impassable substrates by Yersinia type III secretion machines.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 36 citations in OpenAlex.
- Evolution of N-terminal mechanical lability as a determinant for Type III secretion.Protein science : a publication of the Protein Society · 2026Article
- A Type III secretion system effector evolved to be mechanically labile and initiate unfolding from the N-terminus.bioRxiv : the preprint server for biology · 2026Article
- Noncanonical calcium binding motif controls folding of HopQ1, a Pseudomonas syringae type III secretion effector, in a pH-dependent manner.Scientific reports · 2024Article
- Overexpression of T3SS translocation signals inInfection and immunity · 2024Article
- Recruitment of heterologous substrates by bacterial secretion systems for transkingdom translocation.Frontiers in cellular and infection microbiology · 2023Review
- Article
- Identification of type III secretion substrates of Chlamydia trachomatis using Yersinia enterocolitica as a heterologous system.BMC microbiology · 2014Article
- Identification of secreted bacterial proteins by noncanonical amino acid tagging.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Translational regulation of Yersinia enterocolitica mRNA encoding a type III secretion substrate.The Journal of biological chemistry · 2013Article
- Poison domains block transit of translocated substrates via the Legionella pneumophila Icm/Dot system.Infection and immunity · 2013Article
- RfaL is required for Yersinia pestis type III secretion and virulence.Infection and immunity · 2013Article
- YopK controls both rate and fidelity of Yop translocation.Molecular microbiology · 2013Article
- The blueprint of the type-3 injectisome.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Review
- Polymorphisms in the lcrV gene of Yersinia enterocolitica and their effect on plague protective immunity.Infection and immunity · 2012Article
- Article
- Structural instability tuning as a regulatory mechanism in protein-protein interactions.Molecular cell · 2011Article
- Remembering Malcolm J. Casadaban.Journal of bacteriology · 2010Article
- Article
- Elucidation of a pH-folding switch in the Pseudomonas syringae effector protein AvrPto.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Yersinia enterocolitica type III secretion of YopR requires a structure in its mRNA.Molecular microbiology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Type III machines of pathogenic Yersinia spp. transport Yop proteins across the bacterial envelope into host cells. Translational fusions of yopE to the dihydrofolate reductase gene (dhfr) or the beta-galactosidase gene (lacZ) generate hybrid proteins that block type III injection of Yop proteins into host cells, consistent with the canonical view that impassable DHFR and LacZ hybrids jam secretion machines. Mutations in repressors of posttranscriptional gene regulation, Yersinia enterocolitica yscM1 and yscM2 as well as Yersinia pestis lcrQ, relieve the YopE-DHFR-imposed blockade and restore type III injection into host cells. Genetic suppression of the type III blockade does not, however, promote YopE-DHFR secretion. A model is proposed whereby rejection of YopE-DHFR from the secretion pathway inhibits type III gene expression.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.